I just came off of 50mg of Zoloft a month ago after being on it for 10 months and I gained close to 25 lbs despite working out MORE and eating more frequently. Since being off of it, the weight is melting off as my metabolism speeds up, but I really don't have any idea what the hell was going on! My doctor claims that Zoloft doesn't make patients gain weight, but other websites say otherwise. Did anyone else have this problem with any other anti-depressants / anti-anxiety meds? How long will it take to get my metabolism back on track? I have to say I had the exact same problem...about ironic..go on it not to be depressed but wind up gaining weight and being depressed about that. I have to say I had the exact same problem...about ironic..go on it not to be depressed but wind up gaining weight and being depressed about that. I cut my 50mgs in half at the advice of my doctor and was on them for about two weeks until they were gone. I bumped mine back from 50mg to 25mg and dropped some of the weight but not all. I can't remember how long it took me but I dropped about 10 pounds once I lowered the mg. I bumped mine back from 50mg to 25mg and dropped some of the weight but not all. I can't remember how long it took me but I dropped about 10 pounds once I lowered the mg. The following two weeks were really hard as Zoloft has a lot of withdrawal symptoms (I was mainly dizzy- like my blood sugar was too low or something) because of the short half-life. zoloft nursing Seeking help for depression -- and following through with antidepressant medication -- is a courageous and important first step on the road to recovery. But too often, those who take that step find themselves faced with another troubling problem: weight gain. Experts say that for up to 25% of people, most antidepressant medications -- including the popular SSRI (selective serotonin reuptake inhibitor) drugs like Lexapro, Paxil, Prozac, and Zoloft -- can cause a weight gain of 10 pounds or more. "This is a phenomenon that I first noticed years ago when Prozac first came on the market. It didn't initially show up in the clinical trials because most of them were eight to 12 weeks in length, and the weight gain generally occurs with longer use. But it's definitely one of the side effects of this and other antidepressant medications," says Norman Sussman, MD, a psychiatrist and associate dean for postgraduate medical programs at the NYU School of Medicine. A review published in 2003 in the Cleveland Clinic Journal of Medicine stated that while weight gain is a possible side effect with SSRI antidepressant drugs, it may be more likely to occur after six months or more of use. Propranolol alternative Interactions for Zoloft. Apparently metabolized by multiple CYP isoenzymes, with none contributingMetabolism and disposition of the 5-hydroxytryptamine uptake blocker sertraline in the rat and dog. azithromycin side effects in men Metabolic Syndrome Vs Depression. Sertraline Zoloft. by Nervous here comes the bad side of Zoloft. I have just been diagnosed with Metabolic Syndrome. Following oral once-daily ZOLOFT dosing over the range of 50 to 200 mg for 14. The principal initial pathway of metabolism for sertraline is N-demethylation. Sertraline is used for a number of conditions, including major depressive disorder (MDD), obsessive–compulsive disorder (OCD), body dysmorphic disorder (BDD), posttraumatic stress disorder (PTSD), premenstrual dysphoric disorder (PMDD), panic disorder, and social anxiety disorder (SAD). The comparative efficacy of sertraline and TCAs for melancholic depression has not been studied. A 1998 review suggested that, due to its pharmacology, sertraline may be more efficacious than other SSRIs and equal to TCAs for the treatment of melancholic depression. A meta-analysis of 12 new-generation antidepressants showed that sertraline and escitalopram are the best in terms of efficacy and acceptability in the acute-phase treatment of adults with unipolar MDD. Sertraline used for the treatment of depression in elderly (older than 60) patients was superior to placebo and comparable to another SSRI fluoxetine, and TCAs amitriptyline, nortriptyline (Pamelor) and imipramine. Sertraline had much lower rates of adverse effects than these TCAs, with the exception of nausea, which occurred more frequently with sertraline. In addition, sertraline appeared to be more effective than fluoxetine or nortriptyline in the older-than-70 subgroup. placebo in elderly patients showed a statistically significant (that is, unlikely to occur by chance), but clinically very modest improvement in depression and no improvement in quality of life. A meta-analysis on SSRIs and SNRIs that look at partial response (defined as at least a 50% reduction in depression score from baseline) found that sertraline, paroxetine and duloxetine were better than placebo. Sertraline hydrochloride belongs to a class of antidepressant agents known as selective serotonin-reuptake inhibitors (SSRIs). Despite distinct structural differences between compounds in this class, SSRIs possess similar pharmacological activity. As with other antidepressant agents, several weeks of therapy may be required before a clinical effect is seen. SSRIs are potent inhibitors of neuronal serotonin reuptake and terminal autoreceptors. The overall clinical effect of increased mood and decreased anxiety is thought to be due to adaptive changes in neuronal function that leads to enhanced serotonergic neurotransmission. Side effects include dry mouth, nausea, dizziness, drowsiness, sexual dysfunction and headache (see Toxicity section below for a more detailed listing of side effects). Zoloft metabolism Zoloft Sertraline - Side Effects, Dosage, Interactions -, Sertraline Zoloft - Erowid Exp - 'Metabolic Syndrome Vs Xanax how long does it take to work Zoloft and Metabolism. I just came off of 50mg of Zoloft a month ago after being on it for 10 months and I gained close to 25 lbs despite working. Zoloft and Metabolism - Forums ZOLOFT® sertraline HCl Clinical Pharmacology Pfizer Medical. Sertraline - Wikipedia ZOLOFT medication page for healthcare professionals to search for scientific information on Pfizer medications. Also find the package insert, announcements, resources, and ways to connect with. cialis medication Extensively metabolized in the liver. Sertraline metabolism involves N-demethylation, N-hydroxylation, oxidative deamination, and glucuronidation of sertraline. Drug Metab Dispos. 2005 Feb;332262-70. Epub 2004 Nov 16. Sertraline is metabolized by multiple cytochrome P450 enzymes, monoamine oxidases, and.