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    The primary indication of sildenafil is treatment of erectile dysfunction (inability to sustain a satisfactory erection to complete intercourse). Its use is now one of the standard treatments for erectile dysfunction, including for men with diabetes mellitus. Rare but serious adverse effects found through postmarketing surveillance include prolonged erections, severe low blood pressure, myocardial infarction (heart attack), ventricular arrhythmias, stroke, increased intraocular pressure, and sudden hearing loss. Care should be exercised by people who are also taking protease inhibitors for the treatment of HIV infection. Protease inhibitors inhibit the metabolism of sildenafil, effectively multiplying the plasma levels of sildenafil, increasing the incidence and severity of side effects. Those using protease inhibitors are recommended to limit their use of sildenafil to no more than one 25 mg dose every 48 hours. blocker (typically prescribed for hypertension or for urologic conditions, such as benign prostatic hypertrophy) at the same time may lead to low blood pressure, but this effect does not occur if they are taken at least 4 hours apart. Sildenafil Citrate, more commonly known as Viagra, is a drug that is used to treat erectile dysfunction and pulmonary arterial hypertension (PAH). The main function of the drug is to inhibit the enzyme that degrades c GMP, a regulator of blood flow to the penis. The medical uses for Sildenafil Citrate are sexual dysfunction, pulmonary hypertension, and altitude sickness. In 1998, the drug Viagra was introduce as an effective way to treat male erectile dysfunction (MED). It has quickly become one of the most popular and most prescribed drugs in the world. Its annual sales account for over a billion dollars each year. Sildenafil was synthesized by a group of pharmaceutical chemists working at Pfizer’s research facility in England. It was discovered by accident while attempting to produce a drug to treat coronary heart disease.

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