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Discussion in 'xenical and alcohol' started by RT55, 26-May-2020.

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    I’ve just finalized my contract for the 2018 season with the Cleburne Railroaders in the American Association. Cleburne is a suburb of Fort Worth and is in the southwest portion of the Greater Dallas Area. The weather is always hot and humid, there’s always wind at The Depot and the entire stadium is turf (minus the pitching mound). That means the pitch always has thick air for a good break and the ball won’t ever get wet or muddy for a good grip. For legal reasons, he’ll be physically signing his contract “when I arrive in the ballpark in early May so that the contract is solely in the jurisdiction of Texas.” Congratulations, Chris! *** Fans of Phil Niekro knuckleball metaphors and nerve-wracking national politics will appreciate an April 12 post at The Rio Norte Line blog. (The allusion is to Ayn Rand’s novel But this [political] playpen ain’t your normal playpen—this is the Octagon with Conor Mc Gregor on one side and Tito Ortiz on the other…. There is more movement in our day-to-day lives than in a Phil Niekro knuckleball. The junk thrown at us out of DC right now is unhittable…. cialis meme Football and poetry have more in common than you might think. They’re both played on a field of sorts, each with its own specific rules, and each relies on teamwork. There’s a rhythm in the cadence of the QB, in the footwork of receivers. There are plosive sounds as vowels and consonants collide, not unlike the onomatopoetic nature of the game. This is the first of several posts about football and poetry, and about how bringing the two together might just be one of the most important undertakings of my writing life. : it is the deepest part of autobiography.” – Robert Penn Warren I’ve been called an intuitive poet. That’s another way of saying, I don’t have a formal background steeped in meter, or in rhythm and rhyme, or in the nuances of the line.

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  8. Puck Moderator

    The drug Metformin is used to treat insulin resistance in pre-diabetics and women with PCOS. It is also used by some bodybuilders to get back into ketosis after consuming a large amount of carbohydrates. I would like to know if Metformin has a negative effect on muscle protein synthesis. Metformin inhibits m TOR activity(1) and m TOR is required for muscle protein synthesis(2). This leads me to conclude that Metformin could decrease muscle protein synthesis. Metformin antagonizes m TOR secondary to activating AMPK (the two work in a sort of antagonistic counterbalancing relationship), but AMPK activation itself will increase glucose uptake into a myocyte (which then promotes muscle protein synthesis). While it seems more hindering than beneficial to muscle growth on its own, it is possible that physical exercise makes the issue somewhat negligible. From what I've heard with user reports of berberine (AMPK activator with similar potency and mechanism to metformin) it doesn't really do all that much with muscle growth when paired with exercise; never heard of anybody outright failing to build muscle with berberine or Metformin. Please correct me if I am wrong but the take home message is AMPK activation by Metformin (or berberine) can cause a reduction in MPS but increased glucose uptake caused by AMPK activation promotes MPS so it may override the reduction. New route to Metformin Hydr. - MDPI diflucan 150 mg tablet Metformin Inhibits Hepatic mTORC1 Signaling via Dose-Dependent. Metformin and inhibition of muscle protein synthesis - reddit
     
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