Page 290 15 Cancer of the liver, biliary tract and pancreas Primary liver cancer, 290 Hepatocellular carcinoma (hepatoma), 290 Angiosarcoma, 293 Hepatoblastoma, 293 Cancer of the gallbladder and biliary tract, 293 Incidence and aetiology, 293 Pathology, 293 Clinical features, 294 Diagnosis, 294 Treatment, 294 Cancer of the exocrine pancreas, 296 Incidence and aetiology, 296 Pathology, 296 Investigation and diagnosis, 299 Treatment, 299 Neuroendocrine tumours of the gastrointestinal tract, 301 Carcinoid tumours, 301 Endocrine tumours of the pancreas, 303 Multiple endocrine neoplasms, 304 Insulinoma, 304 Gastrinoma (ZollingerEllison syndrome), 305 Vipoma (VernerMorrison syndrome), 306 Glucagonoma, 306 Somatostatinoma, 306 Treatment of advanced neuroendocrine (enterohepatic) tumours, 306 Primary liver cancer Primary cancer of the liver (predominantly hepatocellular carcinoma, HCC) is a major global health problem, being the fifth most common cancer in men and the seventh in women. 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