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    PO administration: 0.1-0.3 mg q4-6hr; increase by 0.1 mg/day to 0.15-0.75 mg/day if required; do not exceed 2.4 mg/day TD administration: 100-200 mcg/day patch q7Days; initiate 0.1-0.3 mg PO q4-6hr for first 2 days to allow for adequate drug levels Not recommended as routine treatment for hypertension (Beers criteria) Potential for orthostatic hypotension and adverse CNS effects May cause bradycardia Immediate release: Lower initial doses than for nongeriatric adult dosing, as well as gradual adjustments, are recommended Extended release: May require lower initial dose than for nongeriatric adult dosing Skin reactions; patch (15-50%) Dry mouth (40%) Somnolence (19-38%) Headache (19-29%) Fatigue (13-24%) Drowsiness (33%) Dizziness (13-16%) Hypotension, epidural (45%) Postural hypotension, epidural (32%) Anxiety (11%) Epidural clonidine is not recommended for obstetric postpartum or perioperative pain management because the risk of hemodynamic instability (eg, hypotension, bradycardia) may be unacceptable in this population Dilute product with strength of 500 mcg/m L prior to use Epidural: Hemodynamically unstable patients (risk of severe hypotension) Do not discontinue suddenly (risk of rebound hypertension) Patch: May need to remove if severe erythema and/or localized vesicle formation develop at application site or generalized rash; consult physician Severe coronary insufficiency May cause xerostomia Recent MI Cerebrovascular disease Chronic renal failure Raynaud's disease Thromboangiitis obliterans History of depression (may exacerbate depression in cancer patients) May impair ability to perform hazardous tasks Remove patch before MRI (may cause burns) Hypotension may occur; usually responsive to IV fluids and, if necessary, appropriate parenterally administered pressor agents Cardiac conduction abnormalities: Sympatholytic action may worsen sinus node dysfunction and atrioventricular (AV) block, especially if coadministered with other sympatholytic drugs Titrate slowly and monitor vital signs frequently in patients at risk for hypotension, heart block, bradycardia, syncope, cardiovascular disease, vascular disease, cerebrovascular disease or chronic renal failure; measure heart rate and blood pressure prior to initiation of therapy, following dose increases, and periodically while on therapy; avoid concomitant use of drugs with additive effects unless clinically indicated; advise patients to avoid becoming dehydrated or overheated Epidural administration may result in mild respiratory depression (usually with higher than recommended dose) Use with caution in cerebrovascular disease Avoid as first line antihypertensive in the elderly due to high risk for adverse side effects Children may be particularly susceptible to hypertensive episodes when experiencing GI illnesses that lead to vomiting Discontinue oral immediate release formulations within 4 hr of surgery; restart as soon as possible following surgery Due to different pharmacokinetic profiles, oral formulations are not interchangeable with extended release on a mg-mg basis due to different pharmacokinetic profiles Central sympatholytic via stimulation of central alpha receptors; results in reduced sympathetic outflow, causing decreased PVR, HR, BP, and renal vascular resistance; produces presynaptic and postjunctional alpha-2 adrenoreceptor analgesia by preventing pain signal transmission to brain Postsynaptic alpha2-agonist stimulation may regulate subcortical activity in the prefrontal cortex, which may regulate the area of the brain responsible for attention, emotions, and behaviors, and thereby reduces hyperactivity, distractibility, and impulsiveness The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information. generic for valacyclovir Your doctor will tell you how much of this medicine to use and how often. Your dose may need to be changed several times in order to find out what works best for you. Do not use more medicine or use it more often than your doctor tells you to. In addition to the use of this medicine, treatment for your high blood pressure may include weight control and changes in the types of foods you eat, especially foods high in sodium (salt). Your doctor will tell you which of these are most important for you. You should check with your doctor before changing your diet. Many patients who have high blood pressure will not notice any signs of the problem. It is very important that you take your medicine exactly as directed and that you keep your appointments with your doctor even if you feel well.

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    Pheochromocytoma Diagnosis Off-label. Clonidine suppression testing 0.3 mg PO for 60-80 kg patient; obtain blood sample 3 hours after administration to. lasix lasts six hours Clonidine is also used and as an aid in smoking cessation therapy and to diagnose pheochromocytoma a tumor that develops on a gland near the kidneys and may cause high blood pressure and fast heart rate. Gelatin, glycerin, lactose, and magnesium stearate. The Catapres 0.1 mg tablet also contains FD&C Blue No.1 and FD&C Red No.3. Clonidine hydrochloride.

    Oral: -Initial dose: 0.1 mg orally 2 times a day (morning and bedtime) -Titration: Increments of 0.1 mg orally per day may be made at weekly intervals to desired response -Maintenance dose: 0.2 to 0.6 mg orally per day in divided doses -Maximum dose: 2.4 mg orally per day in divided doses Comments: -Taking the larger portion of the oral daily dose at bedtime may minimize transient adjustment effects of dry mouth and drowsiness Transdermal patches: -Initial dose: 0.1 mg/24 hr patch applied every 7 days -Maintenance dose: If, after 1 to 2 weeks the desired reduction in blood pressure is not achieved, increase the dosage by adding another 0.1 mg/24 hr patch or changing to a larger system -Maximum dose: Doses above two 0.3 mg/24 hr patches applied every 7 days is usually not associated with additional efficacy Comments: -The transdermal patch should be applied to a hairless area of intact skin on the upper outer arm or chest. -Each new patch should be applied on a different skin site from the previous location. -If the patch loosens during 7-day wearing, the adhesive cover should be applied directly over the system to ensure good adhesion. -There have been rare reports of the need for patch changes prior to 7 days to maintain blood pressure control. -When substituting patches for the oral formulation or for other antihypertensive drugs, physicians should be aware that the antihypertensive effect of the patches may not commence until 2 to 3 days after initial application; therefore, gradual reduction of prior drug dosage is advised. Some or all previous antihypertensive treatment may have to be continued, particularly in patients with more severe forms of hypertension. Use: For hypertension, alone or in combination with other antihypertensive agents Epidural infusion: -Initial dose: 30 mcg/hr as a continuous infusion -Titration: May be titrated up or down depending on pain relief and occurrence of adverse events Maximum dose 40 mcg/hr as a continuous infusion Use: For the treatment of severe pain (in combination with opiates) in cancer patients that is not adequately relieved by opioid analgesics alone. Clonidin ist eine chemische Verbindung aus der Gruppe der Imidazoline. Es wird als Arzneistoff zur Behandlung der arteriellen Hypertonie (Bluthochdruck), unterstützend während Narkosen und bei der Dämpfung von Entzugserscheinungen eingesetzt. Clonidin ist ein α Das ursprüngliche Hauptanwendungsgebiet von Clonidin (Behandlung der arteriellen Hypertonie) wurde in den sechziger Jahren eher zufällig erschlossen: Bei Tests verschiedener Substanzen zum Abschwellen der Nasenschleimhaut fiel beim Clonidin die starke Verringerung der Herzfrequenz (Bradykardie) und die Senkung des Blutdruckes (Hypotonie) auf. Später wurden im Tierexperiment auch schmerzlindernde und beruhigende Wirkkomponenten nachgewiesen. Insgesamt resultieren folgende Wirkungen -Adrenozeptoren der Präsynapse einen hemmenden Einfluss auf die efferenten sympathischen Fasern. An den Barorezeptoren der Arteria carotis werden so bei einem Anstieg des arteriellen Blutdrucks eine Hemmung des Sympathikotonus und eine Stimulierung des Parasympathikus mit der Folge einer Blutdrucksenkung erreicht. Die Signaltransduktion erfolgt im Wesentlichen GPCR-vermittelt (vorwiegend inhibitorisches G-Protein) über präsynaptische α-Rezeptoren sitzen an verschiedensten Stellen im Zentralnervensystem (Hypothalamus, Thalamus, Medulla oblongata, Formatio reticularis, Locus caeruleus, Nucleus tractus solitarii u.

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