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    Received Date: February 02, 2017; Accepted Date: March 10, 2017; Published Date: March 13, 2017 Citation: Tang X, Cao Y, Yu J, Shi R, Huang Y, et al. (2017) Development and Validation of HPLC Methods for the Determination of Propranolol Hydrochloride and Hydrochlorothiazide Related Substances in Combination Tablets. Int J Drug Dev & Res 9: 24-29 A recent study shows that propranolol hydrochloride (PRO) related substances may also reduce the stability of tablets in storage. pharmacopoeia could not detect PRO related substances. Therefore, it is necessary to control the level of PRO related substances in tablets. To overcome this, we developed a new method which can detect PRO, hydrochlorothiazide (HCT) and all of their impurities. In this study, validation studies were also performed, linear relationship with a good correlation coefficient (r2)0.990 was found of both PRO impurities and HCT impurities in the range of 0.12-0.60, and 0.15-0.75 μg/ml respectively. Acceptable intra- and inter- assay precisions were achieved. Accuracy and robustness were reported as percent recovery, and all the recoveries were at the range of 70-130%. Combination Antihypertensive Drugs Recommendations for Use - AAFP prednisolone structure What is Propranolol / HCTZ? - GoodRx Propranolol and Hydrochlorothiazide - Side Effects, Uses, Dosage.
     
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