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Tamoxifen Citrate(Nolvadex) powder Often referred to as an anti-estrogen, it is actually both an antagonist and agonist. It is a selective estrogen-receptor modulator (SERM) that works both by decreasing factors that increase the growth of breast cells and increasing factors that decrease the growth of breast cells. Tamoxifen Citrate powder is also know as Nolvadex powder (CAS 54965-24-1). (1)Usual Adult Dose for Breast Cancer: For the treatment of metastatic breast cancer in women and men: 20 to 40 mg orally Dosages greater than 20 mg should be given in divided doses (morning and evening). For the treatment of women with Ductal Carcinoma in Situ, following breast surgery and radiation: 20 mg orally daily for 5 years. To reduce the incidence of breast cancer in women at high risk for breast cancer: 20 mg orally daily for 5 years. 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