Chloroquine ferroquine and ruthenoquine structure

Discussion in 'Reliable Pharmacy' started by edibebuild, 01-Mar-2020.

  1. ZZe Well-Known Member

    Chloroquine ferroquine and ruthenoquine structure


    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    To understand how chloroquine CQ enhances transgene expression in polycation-based, nonviral gene delivery systems, a number of CQ analogues with variations in the aliphatic amino side chain or in the aromatic ring are synthesized and investigated. Ferroquine Ferrocenyl derivative of the organic antimalarial drug chloroquine. In contrast to the parent organic drug, Ferroquine is also active on Plasmodium falciparum strains which are resistant to chloroquine. Ferroquine is the most advanced organometallic-containing drug candidate. Cisplatin cis-diamminedichloroplatinumII was used as a positive control for cell death. Chloroquine and ferroquine were also used as control. All tested compounds were found to lower the viability of the tested cell cultures, with increasing detrimental effect with increasing compound concentration.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    Chloroquine ferroquine and ruthenoquine structure

    Metal-chloroquine derivatives as possible anti-malarial., Toward organometallic antischistosomal drug candidates

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  7. Ferroquine FQ, or SSR97193, is a novel antimalarial drug currently in phase I clinical trials. FQ is a unique organometallic compound designed to overcome the chloroquine CQ resistance problem. FQ revealed to be equally active on CQ-sensitive and CQ-resistant Plasmodium falciparum laboratory strains and field isolates.

    • Assessment of Plasmodium falciparum resistance to..
    • Structural Characteristics of Chloroquine-Bridged..
    • Chloroquine C18H26ClN3 - PubChem.

    The 24 hours post-incubation all newly transformed schistosomula NTS exposed to 33.3 µM Ferroquine FQ, hydroxyl-ferroquine FQ-OH and Ruthenoquine RQ shows strongly reduced viabilities. 72 hours post-incubation all NTS exposed to 33.3 µM RQ have died, while Ferroquine and FQ-OH treated worms are strongly affected but still alive. To understand how chloroquine CQ enhances transgene expression in polycation-based, nonviral gene delivery systems, a number of CQ analogues with variations in the aliphatic amino side chain or in the aromatic ring are synthesized and investigated. Our studies indicate that the aliphatic amino moiety of CQ is essential to provide increased gene expression. Ferroquine is a hemozoin inhibitor potentially for the treatment of malaria. MedKoo Biosciences, Inc. Leading supplier of anticancer chemical reagents and kinase inhibitors

     
  8. p0stgun Well-Known Member

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  9. adman Guest

    Chloroquine is the generic form of the brand-name prescription medicine Aralen, which is used to prevent and treat malaria — a mosquito-borne disease caused by a parasite — and to treat amebiasis, an infection of the intestines caused by a parasite. Malaria and Parkinson's Disease - Treato Anti-Malaria Drugs May Offer Protection Against Parkinson’s. Effects of chloroquine on viral infections an old drug.
     
  10. inkubus Well-Known Member

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