Additionally, another exception occurred while executing the custom error page for the first exception. : September 14, 2016 Chief complaint: Whirling and flashing lights A 57-year-old female presented to the Ophthalmology clinic at UIHC complaining bilateral central photopsias for the past two years. Chloroquine in cancer therapy a double edged sword of autophagy Plaquenil sarcoidosis hypercalcemia Electroretinography ERG is an eye test that detects function of the retina the light-detecting portion of the eye. The retina is comprised of layers of specialized cells, including photoreceptors rods and cones, that detect light and ganglion cells that transmit images to the brain. Multifocal ERGs better quantify retinal toxicity than full-field ERGs. Below are mfERGs of several patients with Plaquenil toxicity. Plaquenil first affects small areas between 5-15 degrees from fovea eventually progressing to produce a ring scotoma. Figs. 47 and 48. Fig. 47. Multifocal ERG ring ratios reveal retinal toxicity in a surprisingly large fraction of patients taking hydroxychloroquine who are referred for evaluation and have no previous history of eye disease. We find the use of ring ratios to be a sensitive measure of dysfunction in ocular hydroxychloroquine toxicity. The data also suggest a testing. She was previously treated with hydroxychloroquine (Plaquenil) 200mg bid (6.5mg/kg) for 10 years, which was stopped one year prior to presentation. She suffered from Sjogren syndrome and inflammatory arthritis and was currently treated with prednisone and methotrexate. Multifocal erg for plaquenil AMERICAN COLLEGE OF RHEUMATOLOGY, The Electroretinogram and Electro-oculogram Clinical Applications by. Is hydroxychloroquine hepatotic To determine the validity of multifocal electroretinography mfERG as a screening tool for detecting chloroquine Aralen, Sanofi Aventis, Bridgewater, NJ CQ and hydroxychloroquine Plaquenil. PDF Multifocal ERG Guiding Therapy in a Case of Hydroxychloroquine.. Detection of Early Hydroxychloroquine Retinal Toxicity Enhanced by Ring.. Multifocal ERG in Practice -. Electroretinography ERG In 2015, Tzekov and Madow 8 stated that birdshot chorioretinopathy BSCR is a rare form of autoimmune posterior uveitis that can affect the visual function and, if left untreated, can lead to sight-threatening complications and loss of central vision. Background The purpose of this study was to evaluate and compare full‐field electroretinography ERG and multifocal electroretinography mfERG results in detecting retinal dysfunction in a large number of asymptomatic patients treated with hydroxychloroquine Hy. Assessing hydroxychloroquine toxicity by the multifocal ERG. Twenty patients on Plaquenil treatment were evaluated for retinal toxicity using the EOG and the.