Multifocal erg plaquenil toxicity

Discussion in 'North West Pharmacy Canada' started by SerEzhik, 16-Mar-2020.

  1. book1973 Guest

    Multifocal erg plaquenil toxicity


    She suffered from Sjogren syndrome and inflammatory arthritis and was currently treated with prednisone and methotrexate. She was previously treated with hydroxychloroquine (Plaquenil) 200mg bid (6.5mg/kg) for 10 years, which was stopped one year prior to presentation.

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    Twenty patients on Plaquenil treatment were evaluated for retinal toxicity using the EOG and the mfERG. Group 1 comprises 15 patients 30 eyes with normal EOG. From these patients 11 22 eyes showed normal RRD of mfERG in area 1 and area 2. The rest four patients 8 eyes the RRD were reduced. Hydroxychloroquine Plaquenil and chloroquine cause ocular toxicity, including the cornea, ciliary body, and retina. Chloroquine can cause cataract; however, no reports of hydroxychloroquine and cataract have been reported. Using multifocal ERG ring ratios to detect and follow Plaquenil retinal toxicity a review. Abstract. Multifocal ERG ring ratios provide a sensitive and objective method to detect ocular toxicity in patients taking hydroxychloroquine Plaquenil.

    Review of systems: Blurred vision, halos, dry eye, dry mouth, gastroesophageal reflux, joint pain Pupils: Reactive to light in each eye from 5 mm in the dark to 2 mm in the light. Extraocular movements: Full, both eyes (OU) Confrontation visual fields: Full OU Intra-ocular pressure The optic nerves appeared healthy with a 0.3 cup-to-disc ratio. Past Ocular History: None Medical History: Sjogren syndrome and inflammatory arthritis, supraventricular tachycardia, anxiety, depression, peptic ulcer disease Medications: prednisone, methotrexate, amitriptyline, ranitidine, estradiol, tizanidine, diltiazem, Restasis Allergies: codeine, droperidol Family History: heart disease, arthritis, cancer Social History: occasional alcohol but no tobacco or intravenous drug use.

    Multifocal erg plaquenil toxicity

    Assessing hydroxychloroquine toxicity by the multifocal ERG., Hydroxychloroquine toxicity - EyeWiki

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  3. Purpose To evaluate the utility of ring ratios in detecting hydroxychloroquine HCQ related retinal toxicity using the 103-hexagon multifocal electroretinogram mfERG. Design Retrospective cross-sectional study. Methods 23 patients taking HCQ were consecutively evaluated for retinal toxicity and divided into those without HCQ-non-toxic group and with documented visual field loss HCQ-toxic.

    • Quantitative assessment of the 103-hexagon multifocal..
    • Using multifocal ERG ring ratios to detect and follow..
    • Hydroxychloroquine Plaquenil Toxicity and..

    The abnormalities on multifocal ERG corresponded with the patients’ subjective descriptions and the visual field depiction of their pericentral scotomas. All affected patients had been taking hydroxychloroquine for at least 7 years. One patient with generalized depression on multifocal ERG had possible hydroxychloroquine retinopathy. Patients who present with Plaquenil toxicity typically exhibit depigmentation that is located circumferentially around the macula, giving it a “bull’s eye” pattern. Consequently, this clinical finding is often termed bull’s eye maculopathy. Multifocal ERG has the potential to be used as an early screening device for patients taking high doses of hydroxychloroquine before they become symptomatic or show clinical signs of toxicity. Because stabilization and perhaps reversibility are more likely if retinopathy is detected early, the development of multifocal ERG for detection of the earliest stages of hydroxychloroquine retinopathy is paramount. 15

     
  4. rassKas User

    Applies to hydroxychloroquine: oral tablet Along with its needed effects, hydroxychloroquine may cause some unwanted effects. Hydroxychloroquine Plaquenil Side Effects & Dosage for. Hydroxychloroquine 10% stop from side effects — Donovan Hair. Will you have Hair loss with Plaquenil - eHealthMe
     
  5. MsPromoter Moderator

    Primaquine - an overview ScienceDirect Topics Chloroquine, primaquine, quinine, and their analogs are among the most successful drugs used to treat malaria, 87 exhibiting a rapid response, accumulating in the parasite, 88 and interfering with the way it metabolizes the host’s hemoglobin, blocking the polymerization of heme into hemozin.

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  6. InfoDog Guest

    Plaquenil What You Need to Know - Kaleidoscope Fighting Lupus Plaquenil is a slow-acting drug, meaning that it can take up to 6 months to experience the full benefits of this medication, but it is possible for symptoms to improve in as few as 1 or 2 months. Plaquenil and other antimalarials are the key to controlling lupus long-term, and some lupus patients may be on Plaquenil for the rest of their lives.

    Hydroxychloroquine - Side Effects, Dosage, Interactions.