People living with inflammatory arthritis, which includes rheumatoid arthritis (RA), psoriatic arthritis, and ankylosing spondylitis, as well as other types of arthritis, know that it causes your immune system to mistakenly attack your body’s own cells. But the condition also throws out of whack how your body deals with foreign invaders of the germ kind. Interaction with lexapro and plaquenil When taking aralen should i be using an antiacid Plaquenil and nodules Drug information on Hydroxychloroquine for health care professionals. Pharmacology. Mechanism of Action Immune modulator. Hydroxychloroquine, an alkylated 4-aminoquinoline, is a hydroxylated form of chloroquine and has a biological mechanism of action similar to chloroquine’s. In 2003, a novel mechanism was described wherein hydroxychloroquine inhibits stimulation of the toll-like receptor TLR 9 family receptors. TLRs are cellular receptors for microbial products that induce inflammatory responses through activation of the innate immune system. The mechanism is unknown. Combining telbivudine Tyzeka and hydroxychloroquine may increase the risk of unexplained muscle pain, tenderness, or weakness because both drugs cause such side effects. Hydroxychloroquine suppresses the immune system and should not be combined with drugs that also suppress the immune system or live vaccines. One Mayo Clinic study found that people with RA have twice the risk of general infection as people without. “It has been known for more than 50 years that patients with inflammatory arthritis are more susceptible to infections such as colds and flu,” says Chase Correia, MD, a Northwestern University Medicine rheumatologist and a member of the American College of Rheumatology Communications and Marketing Committee. Hydroxychloroquine suppress immune system Plaquenil and its affect on the immune system DailyStrength, Hydroxychloroquine - Wikipedia Chloroquine doseHydroxychloroquine effects on tastePlaquenil and coq10Hydroxychloroquine rheumatoid arthritis mechanismHydroxychloroquine and slurred speech The suppression of fungal nail infection during six months of HCQ therapy, as well as the recurrence of the infection, after HCQ was stopped, could be a sign of fungistatic effect of HCQ. If further in vitro and in vivo investigations confirm such an effect, then other mechanisms should be stipulated, different from current immune phagocytosis. Fungistatic effect of hydroxychloroquine, lessons from a case. Hydroxychloroquine Plaquenil Side Effects & Dosage for Malaria. Immunosuppressant Drugs A Complete Overview. A recent study published International Immunopharmacology that hydroxychloroquine improved rosacea in rosacea-like mice and mast cells MCs and investigated the effects of HCQ treatment for rosacea patients. The paper concludes, In vitro, HCQ suppresses LL37-induced MCs activation in vitro, incl. Definition NCI A 4-aminoquinoline with immunosuppressive, antiautophagy, and antimalarial activities. Although the precise mechanism of action is unknown, hydroxychloroquine may suppress immune function by interfering with the processing and presentation of antigens and the production of cytokines. Basically, the immune system is a bit out of control. Plaquenil works by suppressing the immune system. Unfortunately you can't tell it to attack just the germs so you suppress all of its function to spare your healthy tissue- in your husband's case, his eyes, mouth, throat. NOTE Plaquinil and hydroxychloroquine are essentially the same drug.