Dengue virus chloroquine

Discussion in 'International Pharmacy' started by Dr. Black, 18-Mar-2020.

  1. polasatoe Moderator

    Dengue virus chloroquine


    -Suppressive therapy should continue for 8 weeks after leaving the endemic area. Approved indication: For the suppressive treatment of malaria due to Plasmodium vivax, P malariae, P ovale, and susceptible strains of P falciparum CDC Recommendations: 300 mg base (500 mg salt) orally once a week Comments: -For prophylaxis only in areas with chloroquine-sensitive malaria -Prophylaxis should start 1 to 2 weeks before travel to malarious areas; should continue weekly (same day each week) while in malarious areas and for 4 weeks after leaving such areas.

    Chloroquine for vivax malaria Plaquenil toenails

    Chloroquine CQ, a cheap and well-tolerated drug, inhibits the growth of dengue viruses in the laboratory with concentrations achievable in the body. To measure the antiviral efficacy of CQ in dengue, we conducted a study involving 307 adults with suspected dengue. Chloroquine, an Endocytosis Blocking Agent, Inhibits Zika Virus Infection in Different Cell Models. Viruses 8, https//doi.org/10.3390/v8120322 2016. Members of the quinoline family, such as chloroquine and hydroxychloroquine, have shown antiviral activity against several viruses, such as coronaviruses, human immunodeficiency virus, and respiratory syncytial virus.

    Approved indication: For acute attacks of malaria due to P vivax, P malariae, P ovale, and susceptible strains of P falciparum CDC Recommendations: Chloroquine-sensitive uncomplicated malaria (Plasmodium species or species not identified): 600 mg base (1 g salt) orally at once, followed by 300 mg base (500 mg salt) orally at 6, 24, and 48 hours Total dose: 1.5 g base (2.5 g salt) Comments: -For the treatment of uncomplicated malaria due to chloroquine-sensitive P vivax or P ovale, concomitant treatment with primaquine phosphate is recommended. 60 kg or more: 1 g chloroquine phosphate (600 mg base) orally as an initial dose, followed by 500 mg chloroquine phosphate (300 mg base) orally after 6 to 8 hours, then 500 mg chloroquine phosphate (300 mg base) orally once a day on the next 2 consecutive days Total dose: 2.5 g chloroquine phosphate (1.5 g base) in 3 days Less than 60 kg: First dose: 16.7 mg chloroquine phosphate/kg (10 mg base/kg) orally Second dose (6 hours after first dose): 8.3 mg chloroquine phosphate/kg (5 mg base/kg) orally Third dose (24 hours after first dose): 8.3 mg chloroquine phosphate/kg (5 mg base/kg) orally Fourth dose (36 hours after first dose): 8.3 mg chloroquine phosphate/kg (5 mg base/kg) orally Total dose: 41.7 mg chloroquine phosphate/kg (25 mg base/kg) in 3 days Comments: -Concomitant therapy with an 8-aminoquinoline compound is necessary for radical cure of malaria due to P vivax and P malariae.

    Dengue virus chloroquine

    Research Article Chloroquine Inhibits Dengue Virus Type 2., Repurposing of the anti-malaria drug chloroquine for Zika Virus.

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  7. Zika virus ZIKV is an emerging virus which can cause birth defects, however there are currently no effective treatments or vaccines. We tested the effects of 16 verified Ebola virus cell entry inhibitors on ZIKV infection, and found that chloroquine CQ could prevent ZIKV infection in cell cultures, consistent with results from a previous study.

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    Zika virus ZIKV is an arthropod-borne virus, transmitted by Aedes mosquitoes, that belongs to the Flavivirus genus, which also includes other pathogens such as West Nile virus WNV, yellow fever virus YFV, Japanese encephalitis virus JEV, and dengue virus DENV. Zika virus was first isolated from a sentinel monkey in the Zika forest in Uganda in 1947. Since then, ZIKV has been isolated from humans and mosquitoes throughout Africa and Southeast Asian countries. Chloroquine CQ, a cheap and well-tolerated drug, inhibits the growth of dengue viruses in the laboratory with concentrations achievable in the body. To measure the antiviral efficacy of CQ in dengue, we conducted a study involving 307 adults with suspected dengue. Patients received a 3-day oral dosage of placebo or CQ early in their illness. The antimalarial drug chloroquine has been suggested as a treatment for Ebola virus infection. Chloroquine inhibited virus replication in vitro, but only at cytotoxic concentrations. In mouse and hamster models, treatment did not improve survival. Chloroquine is not a promising treatment for Ebola. Efforts should be directed toward other drug classes.

     
  8. MarPRO User

    Hydroxychloroquine is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Plaquenil Hydroxychloroquine Uses, Dosage, Side Effects. Hydroxychloroquine Plaquenil Side Effects & Dosage for. Hydroxychloroquine Oral Uses, Side Effects, Interactions.
     
  9. Wеber Guest

    Plaquenil Hydroxychloroquine Uses, Dosage, Side Effects. PLAQUENIL should be administered with caution in patients having glucose-6-phosphate dehydrogenase G-6-PD deficiency. Dermatologic Effects. Dermatologic reactions to PLAQUENIL may occur and, therefore, proper care should be exercised when it is administered to any patient receiving a drug with a significant tendency to produce dermatitis.

    Psoriasis On The Rebound
     
  10. dovgyi Well-Known Member

    Plaquenil Hydroxychloroquine - Side Effects, Dosage. Common Side Effects of Plaquenil. You can reach a poison-control center at 800 222-1222. Missed Dose of Plaquenil. If you miss a dose of Plaquenil, take it as soon as your remember.

    Plaquenil side effects" Lupus Community - Support Group