One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine (Plaquenil), a chloroquine derivative. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus. Plaquenil 200 mg film-coated tablets Mechanism of chloroquine resistance Remember, any patient who is at a high risk for Plaquenil toxicity should be examined on an annual basis following the baseline exam. The goal of monitoring/screening is to identify early macular damage prior to irreversible vision loss or even before visible signs of bull’s eye maculopathy. Clinical Guidelines RCOphth Clinical Guidelines. The aim of College Clinical Guidelines is to identify the best medical evidence, set standards of patient care and ensure patient safety, providing a benchmark for outcomes within which high quality Ophthalmology can be practiced in the UK health service. Of course the aim is avoid drug related retinal toxicity, which on ophthalmic examination, appears as the classic Bull’s eye change affecting the macula. Once retinal toxicity from hydroxychloroquine occurs, it is thought that the retinal changes are permanent and the disease can progress even if hydroxychloroquine is stopped for 1 to 3 years. It is imperative that patients and physicians are aware of and watch for this drug’s ocular side effects. Retinal toxicity from hydroxychloroquine is rare, but even if the medication is discontinued, vision loss may be irreversible and may continue to progress. Hydroxychloroquine eye exam guidance ncbi Chloroquine And Hydroxychloroquine Toxicity - nih.gov, Clinical Guidelines - The Royal College of Ophthalmologists Normal dosage daily for plaquenilHydroxychloroquine dosing lymePlaquenil and uveitisHydroxychloroquine and ocular toxicity recommendations on screening 2009Plaquenil ogen Hydroxychloroquine HCQ is an anti-malarial medication that has in recent times been utilized as treatment for a variety of autoimmune diseases, such as rheumatoid arthritis and systemic lupus erythematosus, and other inflammatory and dermatologic conditions. Retinal toxicity from HCQ, and its analog, chloroquine, has been recognized for many years.2,3 By some estimates, in the United. Hydroxychloroquine retinopathy A review of imaging. My Take on New Ocular Screening Guidelines for Plaquenil RheumNow.. Hydroxychloroquine Plaquenil Toxicity and.. Multi-focal Electroretinography mfERG may be considered medically necessary for detecting chloroquine Aralen and hydroxychloroquine Plaquenil toxicity. mfERG is considered experimental, investigational and/or unproven for all other indications, including but not limited to the diagnosis and evaluation of glaucoma and the prediction of. Importance Primary Sjögren syndrome is a systemic autoimmune disease characterized by mouth and eye dryness, pain, and fatigue. Hydroxychloroquine is the most frequently prescribed immunosuppressant for the syndrome. However, evidence regarding its efficacy is limited. Methods/design. HERO is an investigator-initiated, multicentre, randomized, double-blind, placebo-controlled trial. A total of 252 subjects with symptomatic hand OA will be recruited across primary and secondary care sites in the UK and randomized on a 11 basis to active treatment or placebo for 12 months.