Fluorescein angiography and hydroxychloroquine maculopathy screening

Discussion in 'Hydroxychloroquine Sulfate' started by lenxoxo, 08-Mar-2020.

  1. Condenser Well-Known Member

    Fluorescein angiography and hydroxychloroquine maculopathy screening


    She suffered from Sjogren syndrome and inflammatory arthritis and was currently treated with prednisone and methotrexate. She was previously treated with hydroxychloroquine (Plaquenil) 200mg bid (6.5mg/kg) for 10 years, which was stopped one year prior to presentation.

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    A pilot study conducted in 15 patients on chloroquine or hydroxychloroquine therapy found that the 10 patients with known or suspected toxicity—based on standardized visual field testing, fluorescein angiography, or both—all demonstrated significant hyperacuity defects on PHP testing. Fluorescein angiography FA Optical coherence tomography OCT Fundus autofluorescence; Multifocal electroretinograms mf ERG. Early detection of any maculopathy is critical to prevent central visual loss. The Retina Group of New York provides all of these testing modalities and is the only center on Long Island with mf ERG. Treatment Nov 14, 1998 Editor —The articles cited by May et al confirm that the incidence of hydroxychloroquine retinopathy resulting in permanent or progressive visual loss is extremely low. If the drug was introduced today it would be difficult to justify the initiation of a screening programme.

    Review of systems: Blurred vision, halos, dry eye, dry mouth, gastroesophageal reflux, joint pain Pupils: Reactive to light in each eye from 5 mm in the dark to 2 mm in the light. Extraocular movements: Full, both eyes (OU) Confrontation visual fields: Full OU Intra-ocular pressure The optic nerves appeared healthy with a 0.3 cup-to-disc ratio. Past Ocular History: None Medical History: Sjogren syndrome and inflammatory arthritis, supraventricular tachycardia, anxiety, depression, peptic ulcer disease Medications: prednisone, methotrexate, amitriptyline, ranitidine, estradiol, tizanidine, diltiazem, Restasis Allergies: codeine, droperidol Family History: heart disease, arthritis, cancer Social History: occasional alcohol but no tobacco or intravenous drug use.

    Fluorescein angiography and hydroxychloroquine maculopathy screening

    Hydroxychloroquine retinopathy screening, Plaquenil Toxicity Screening - Retina Group of New York

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  7. Apr 20, 2011 There have been reports of color vision defects associated with chloroquinine- and hydroxychloroquinine-related retinal toxicity. 4 Other optional tests included multifocal electrophysiology mfERG testing and fluorescein angiography. There are numerous risk factors that promote the development of maculopathy see “Primary Risk Factors.

    • New Plaquenil Guidelines.
    • Screening for hydroxychloroquine retinopathy Screening..
    • Multimodal Imaging in Plaquenil Toxicity.

    Hydroxychloroquine is a commonly used medication for rheumatoid arthritis, systemic lupus erythematosus, discoid lupus, Sjögren syndrome, juvenile idiopathic arthritis, other mixed connective tissue autoimmune conditions, non-small cell lung cancer, and graft-versus-host disease GVHD, to name a few. Hydroxychloroquine should undergo periodic and comprehensive eye examinations. The aim of the Fig. The bull’s eye pattern of depigmentation associated with chloroquine maculopathy is evident on fundus photographs and highlighted by fluorescein angiography photographs of the a right eye and b left eye; and Fluorescein angiography showed the atrophic window defect characteristic of hydroxychloroquine maculopathy. On June 10, 1999 her Humphrey 10-2 visual field showed an annular scotoma bilaterally. Follow up on December 7, 1999 showed stable 20/50 best-corrected visual acuity and unchanged Humphrey 10-2 visual fields Figure 6, Figure 7.

     
  8. gv0zd New Member

    In some cases, they may not be available in every strength or form as the brand-name drug. Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses Plaquenil Oral Uses, Side Effects, Interactions, Pictures. Plaquenil and Doxycycline hyclate drug interactions.
     
  9. Acouborrons Well-Known Member

    Chloroquine has long been used in the treatment or prevention of malaria from Plasmodium vivax, P. malariae, excluding the malaria parasite Plasmodium falciparum, for it started to develop widespread resistance to it. Chloroquine phosphate where to buy it. REEF2REEF. Chloroquine MedlinePlus Drug Information Medicines for the Prevention of Malaria While Traveling.
     
  10. MAPK New Member

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