The toxicities can be grouped into categories such as pigmentary retinopathies, crystalline retinopathies, retinal vasculopathies, and retinopathies characterized by retinal edema or folds. Here we present a case of topiramate (Topamax, Ortho-Mc Neil Neurologics) causing transient angle closure and retinal folds. Plaquenil for lupus review alkaline inflammation Plaquenil eye exam report Although the incidence of macular toxicity is infrequent with Plaquenil use at a dosage of 200mg or 400mg q.d. its visual impact can be devastating. 2,3. The associated classic retinal toxicity is described as a bull’s eye maculopathy ring of depigmented retinal pigment epithelium that spares the foveal area. The risk of retinal toxicity secondary to hydroxychloroquine can be divided into dose-related and patient-related factors. For the former, it is the maximum daily dosage 400 mg/day, the cumulative dose 1000 g, and the duration of treatment 5 years that appear to be the most important determinants of the risk of toxicity 3. Canthaxanthine is a vitamin A derivative used in the treatment of psoriasis and eczema, and had been used previously as an oral tanning agent. Toxicity has been shown after high-dose oral therapy of greater than 0.5 mg/kg/day. A 26-year-old woman reported to the emergency room with a chief complaint of sudden, painless loss of vision in both eyes. We follow with a review of the literature regarding topiramate toxicity, as well as a brief review of the other major categories of pharmacologic retinal toxicity. Plaquenil induced retinal toxicity A Case of Severe Hydroxychloroquine-Induced Retinal., A Case of Severe Hydroxychloroquine-Induced Retinal Toxicity. U87 chloroquine in vivoPlaquenil botox interaction Many systemic medications may cause retinal toxicity. One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine Plaquenil, a chloroquine derivative. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus. Hydroxychloroquine-Induced Retinal Toxicity - American.. Common Medications That May Be Toxic to the Retina. Plaquenil Toxicity - Symptoms, Treatment, Risk Factors.. Rheumatologists use hydroxychloroquine sulfate Plaquenil, Concordia Pharmaceuticals to treat autoimmune diseases, namely discoid or systemic lupus erythematosus, rheumatoid arthritis, Sjögren syndrome, and malaria. When taken at high doses and for long durations, hydroxychloroquine has been known to cause parafoveal retinal toxicity. However, it can produce irreversible changes to the retina that lead to visual impairment. The aim of this study was to determine the proportion of patients treated with HCQ who develop retinal toxicity and the risk factors for the development of HCQ-induced retinal toxicity among Iranian patients. Note This document contains side effect information about hydroxychloroquine. Some of the dosage forms listed on this page may not apply to the brand name Plaquenil. For the Consumer. Applies to hydroxychloroquine oral tablet. Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some unwanted effects.