Hydroxychloroquine is available as the brand-name drug Plaquenil. Generic drugs usually cost less than the brand-name version. Hydroxychloroquine may be used as part of a combination therapy. Methotrexate and plaquenil Hydroxychloroquine sulfate vs sodium bicarbonate Plaquenil Side Effects by Likelihood and Severity INFREQUENT side effects. If experienced, these tend to have a Severe expression. A Disorder Of The Retina Of The Eye;. RARE side effects. My Rheum. has me on prednisone 10 mg and plaquenil 400 mg. I have only been taking the plaquenil for three weeks. Still have alot of fatigue and have been in a mini flare with fever, rash, mouth sores, weakness and joint pains the past few days. Plaquenil and Prednisone is not even in the same class of drugs. The prednisone is a steriod and the plaquenil is a anti malaria drug. The thing with plaquenil for me is that I don't notice much of anything taking it but when I go off then I flare up and then really notice it. Hydroxychloroquine is used to treat lupus erythematosus and rheumatoid arthritis. It isn’t fully understood how this drug works to treat lupus erythematosus or rheumatoid arthritis. That means you may need to take it with other drugs. It treats malaria by killing the parasites that cause the disease. Plaquenil and prednisone side effects The Stranger Side Effects of Prednisone, Plaquenil - Better Than Prednisone? - HealthBoards Hydroxychloroquine 200 mg price in indiaPlaquenil as it affects the eyes symptomsPlaquenil memory lossPlaquenil making hair fall out Side Effects. Nausea, stomach cramps, loss of appetite, diarrhea, dizziness, or headache may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly. Plaquenil Oral Uses, Side Effects, Interactions.. Prednisone and Plaquenil DailyStrength. Plaquenil & Weight Gain/Loss -. Compare Plaquenil vs. Prednisone, which is better for uses like Lupus, RA and Sjogren's Syndrome. Compare head-to-head ratings, side effects, warnings, dosages, interactions and patient reviews. Patients rated Plaquenil 3.7/5 over Prednisone 3.2/5 in overall satisfaction. My Mom's Dr's wan'ts her to take both Prednisone and Plaquenil together. I have not heard of this being done. I was wondering if anyone has done both med's at the same time and the effects. Mom has Lupus like me, but she was diagnosed when she was 40 yrs old and now she is 58. She has and enlarged heart, diabetes, had a stroke, and failing kidneys. When I was first diagnosed with lupus I was put on prednisone and plaquenil to help control my severe joint inflammation. The prednisone began workiing in 3 days and helped reduce my joint inflammation. I had some issues with the plaquenil, nausea and extremity swelling.