Malaria is common in areas such as Africa, South America, and Southern Asia. This medicine is not effective against all strains of malaria. Chloroquine mechanism Plaquenil level Long-term progression of hydroxychloroquine retinopathy off the drug How effective against malaria is chloroquine This trial is looking at adding hydroxychloroquine to chemotherapy for people with small cell lung cancer that has spread. Lung cancer that has spread is called advanced lung cancer. Recent research shows that a drug called hydroxychloroquine HCQ might help chemotherapy work better. It does this. This trial is looking at adding a drug called hydroxychloroquine HCQ to radiotherapy as treatment for a type of brain tumour called a high grade glioma in people aged 70 or over. The trial is supported by Cancer Research UK. More about this trial Doctors usually treat high grade gliomas with surgery and radiotherapy. Drugs used in chemotherapy, such as hydroxychloroquine, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving trametinib together with hydroxychloroquine may work better in treating patients with pancreatic cancer. Taking hydroxychloroquine long-term or at high doses may cause irreversible damage to the retina of your eye. Hydroxychloroquine is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Hydroxychloroquine clinical trial cancer Clinical Trials Using Hydroxychloroquine - National Cancer., A trial of hydroxychloroquine HCQ with. - Cancer Research UK Spectrum chloroquinePnemonitis treatment plaquenilChloroquine lupus mechanismChloroquine free base Pre-clinical studies have shown enhanced death of prostate cancer cells with treatment of itraconazole combined with hydroxychloroquine. This treatment causes a dramatic increase in the accumulation of free cholesterol with a phenotype reminiscent of Niemann-Pick Syndrome, a neurodegenerative disease characterised by accumulation of free cholesterol in late endosomes/lysosomes due to mutations in NPC1 and NPC2. Phase I/II Study of Hydroxychloroquine With Itraconazole.. Trametinib and Hydroxychloroquine in Treating Patients.. Hydroxychloroquine - Memorial Sloan Kettering Cancer Center. This phase I/II trial studies the side effects and best dose of hydroxychloroquine when given together with palbociclib and letrozole before surgery in treating participants with estrogen receptor positive, HER2 negative breast cancer. Hydroxychloroquine is a substance that decreases immune responses in the body. OUTLINE This is a dose-escalation study of hydroxychloroquine. Patients receive hydroxychloroquine orally PO twice daily BID on days -14 to 84 and aldesleukin intravenously IV every 8 hours on days 1-5 and 15-19. Treatment repeats every 84 days for up to 3 courses in the absence of disease progression or unacceptable toxicity. Indeed, current clinical trials are trying to use chloroquine or hydroxychloroquine, alone or in combination with other drugs to inhibit autophagy during breast cancer therapy since chemotherapy and radiation, regimens that are used to treat breast cancer, are known to induce autophagy in cancer cells.