Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it. Plaquenil letter Plaquenil diagnosis Plaquenil mechanism of action To understand how chloroquine CQ enhances transgene expression in polycation-based, nonviral gene delivery systems, a number of CQ analogues with variations in the aliphatic amino side chain or in the aromatic ring are synthesized and investigated. Mechanism of action Chloroquine basic concentrates in parasite food vacuole acidic. Prevent heme polymerization into hemozoin causing heme accumulation toxic to parasite. Drug complex with heme disrupt cell membrane function. Other mechanism include intercalating of parasite DNA, DNA synthesis inhibition. 7. Chloroquine is a member of quinolone family and is a weak intercalating agent. Chloroquine is used for treating amebiasis, rheumatoid arthritis, discoid and systemic lupus erythematosus. Application The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead. Chloroquine intercalating Chloroquine Oral Uses, Side Effects, Interactions., Chloroquine - SlideShare Hydroxychloroquin safetyIcd 10 plaquenilPlaquenil 250 Chloroquine, like other intercalators, may work by altering three-dimensional structure. For exam- ple, there is evidence that DNA may form left-handed helices Z-DNAin transcriptionally active regions. We have found that chloroquine prevents the transition of DNA to the Z form in vitro, at concentrations as low as 20 Ref. 17. Chloroquine as intercalator a hypothesis revived - ScienceDirect. Chloroquine diphosphate salt powder or crystals, 98.5-101.. Inhibition of malaria parasite growth by quinomycin A and.. Chloroquine Phosphate is an antimalarial 4-aminoquinoline compound used to inhibit growth of malarial parasites. Chloroquine is a weak intercalating agent that was discovered in 1934 by Hans Andersag Bayer It has shown activity against the coronavirus COVID-19 in clinical trials conducted in China. Unwinding of the double strands of the DNA helix is a hallmark feature of intercalating drugs, such as chloroquine, ethidium bromide and m-AMSA. As part of characterization of novel agents, it is often important to know whether a novel compound is a DNA intercalator. Chloroquine is a well known anti-malarial agent, apart from which is a lysosomotropic agent, was used along with intercalating agent like methylene blue and anti-viral agents to treat clinically confirmed CHB patients.