Chloroquine in chikungunya

Discussion in 'Health Canada Drug Database' started by aligarh, 14-Mar-2020.

  1. valeriy71 User

    Chloroquine in chikungunya


    Malaria is common in areas such as Africa, South America, and Southern Asia. This medicine is not effective against all strains of malaria.

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    Chloroquine, which is commonly used to treat febrile illnesses in the tropics, has been shown to inhibit CHIKV replication in vitro. To assess the in vivo effect of chloroquine, two complementary studies were performed i a prophylactic study in a non-human primate model NHP; and ii a curative study "CuraChik", which was performed during. May 17, 2018 Chloroquine, which is commonly used to treat febrile illnesses in the tropics, has been shown to inhibit CHIKV replication in vitro. To assess the in vivo effect of chloroquine, two complementary studies were performed i a prophylactic study in a non-human primate model NHP; and ii a curative study "CuraChik", which was performed during the Reunion Island outbreak in 2006 in a human cohort. Chloroquine is gaining ground as a possible treatment for the symptoms associated with chikungunya, and as an anti-inflammatory agent to combat the arthritis associated with chikungunya virus. A University of Malaya study found that for arthritis-like symptoms that are not relieved by aspirin and non-steroidal anti-inflammatory drugs NSAID, chloroquine phosphate 250 mg/day has given promising results.

    Taking hydroxychloroquine long-term or at high doses may cause irreversible damage to the retina of your eye. Hydroxychloroquine is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus.

    Chloroquine in chikungunya

    How to Recover from Chikungunya with Expert-Approved Treatments, Paradoxical Effect of Chloroquine Treatment in Enhancing.

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  6. On the use of chloroquine for chikungunya

    • PDF On the use of chloroquine for chikungunya Antonio..
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    Nov 17, 2017 Repurposing of the anti-malaria drug chloroquine for Zika Virus treatment and prophylaxis. Quinolone-N-acylhydrazone hybrids as potent Zika and Chikungunya virus inhibitors Roberta K. F. Marra. Efficacy of Chloroquine Against Chikungunya Virus in Vero Cells Mohsin Khan, S. R. Santhosh, Mugdha Tiwari, P. V. Lakshmana Rao, and Manmohan Parida* Division of Virology, Defence Research & Development Establishment DRDE, Gwalior, MP, India The resurgence of Chikungunya virus CHIKV in the form of unprecedented and explosive epi- Chloroquine is in trials as an antiretroviral for HIV-1/AIDS and is being considered in pre-clinical models as a potential agent against chikungunya fever. 44 Other edit

     
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