One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine (Plaquenil), a chloroquine derivative. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus. How long for plaquenil drug eruption to go away Lowered dose of plaquenil Prednisone and hydroxychloroquine Chloroquine phosphate administration Hydroxychloroquine Plaquenil and chloroquine cause ocular toxicity, including the cornea, ciliary body, and retina. Chloroquine can cause cataract; however, no reports of hydroxychloroquine and cataract have been reported. This article focuses upon hydroxychloroquine retinopathy. Doctors generally recommend regular eye exams while on Plaquenil, so that early changes can be caught. Once abnormalities are discovered, toxicity has already occurred. While it may be reversible if caught early, hydroxychloroquine retinopathy is not always reversible. Plaquenil is indicated for the treatment of uncomplicated malaria due to P. falciparum, P. malariae, P. ovale, and P. vivax. Plaquenil is indicated for the prophylaxis of malaria in geographic areas where chloroquine resistance is not reported. Limitations of Use in Malaria • Plaquenil is not recommended for the treatment of complicated malaria. It is imperative that patients and physicians are aware of and watch for this drug’s ocular side effects. Retinal toxicity from hydroxychloroquine is rare, but even if the medication is discontinued, vision loss may be irreversible and may continue to progress. Is plaquenil toxicity reversible Plaquenil Side Effects on Your Eyes and Vision, Taking Plaquenil for Rheumatoid Arthritis Substitute for plaquenilPlaquenil cholesterol In particular, chloroquine and hydroxychloroquine Plaquenil are two such medications, with the potential for retinal toxicity. Given that the retinal damage from these medications is largely irreversible, screening by a retinal specialist is critical to detect early retinal toxicity to try and limit the extent of visual loss. Retinal Screening for Hydroxychloroquine Plaquenil Toxicity. Plaquenil - FDA prescribing information, side effects and uses. Plaquenil Side Effects Common, Severe, Long Term -. Hydroxychloroquine HCQ, sold under the brand name Plaquenil among others, is a medication used for the prevention and treatment of certain types of malaria. Specifically it is used for chloroquine-sensitive malaria. Other uses include treatment of rheumatoid arthritis, lupus, and porphyria cutanea tarda. It is taken by mouth. Retinal toxicity from hydroxychloroquine is rare, but even if the medication is discontinued, vision loss may be irreversible and may continue to progress. It is imperative that patients and physicians are aware of and watch for this drug’s ocular side effects. Hydroxychloroquine is an antimalarial drug, which is also extensively used in the treatment of dermatology and rheumatology. Its side effects, besides ocular toxicity, include gastrointestinal discomforts, such as nausea, vomiting, cramping and diarrhea 1.