It is a disabling and painful condition which can lead to substantial loss of mobility due to pain and joint destruction. I've been off it a few days and thankfully my plumbing is back to normal it seems and the huge acne has stopped/gone. The disease is also systemic in that it often also affects many extra-articular tissues throughout the body including the skin, blood vessels, heart, lungs, and... Since I'm a woman I managed to bypass the plumbing problems while on the prednisone (I'm on 30 mg), but you're right, the acne is BAD!! Considering the state my joints are in though, I suppose that's the least of my problems. Plaquenil severe rash Chloroquine protein degradation Can i use of hydroxychloroquine with sulfur allergy For women, start with 100 pounds, and add 5 pounds for every inch over 5 feet. For men, start with 106 pounds, and add 6 pounds for every inch over 5 feet. The maximum dose of Plaquenil is 6.5 mg/kg of ideal body weight per day, regardless of whether a person is overweight, underweight, or normal weight. Plaquenil takes quite a long time to get to its peak effectiveness depending on what you read, anywhere from 3 months to a year. Unless you are having significant side effects, try to give it at least 6 months before you decide it doesn't work for you. Nov 14, 2006 I can tell you that plaquenil is the safest of all of the DMARDs. If you're going to stay on a DMARD for a long time, plaquenil is the one to be on. Best of luck on the plaquenil. My doctor was only able to find it after I requested a MRI of my hands. Of course neither has the prednisone, sulfasalazine, or methotrexate. Hi guys, I was diagnosed with RA in April 08 and I'm 29 years old. I've been on plaquenil for over 4 months and it hasn't done squat for me. How to tell if plaquenil is working The Risk of Retinal Toxicity with Plaquenil, PLAQUENIL" Rheumatoid Arthritis Community - Support Group What does plaquenil treatColor perception changes in plaquenil Mar 24, 2011 I tell ya, these AI diseases are nothing to sneeze at and neither is bad fibromyalgia. I don't know if we get the fibro worse with AI diseases or what but I was in so much pain. The fatigue was horrible too. I am glad I switched to the cymbalta, perhaps the combination of it and 400 mg of plaquenil will work for me. What next if plaquenil doesn't work?. Plaquenil -. Signs That Your Biologic for RA Isn't Working. If you are taking Plaquenil to treat an inflammatory condition or malaria, you should be aware of the side effects that may occur to your eyes and vision. Plaquenil hydroxychloroquine is in a class of drugs called disease-modifying anti-rheumatic drugs, which are used to decrease inflammation, pain and joint damage. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs. If you have had any eye changes or changes in eyesight due to Plaquenil hydroxychloroquine or drugs like this one. Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria.