Chloroquine resistant falciparum malaria drugs

Discussion in 'Chloroquine Without A Doctors Prescription' started by atp, 04-Mar-2020.

  1. Star-set XenForo Moderator

    Chloroquine resistant falciparum malaria drugs


    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    Plasmodium falciparum, the deadliest form of the malaria parasite, is responsible for the vast majority of the mortality and morbidity associated with malaria infection. Artemisinin Combination Therapies, or ACTs, are currently the frontline treatments against P. falciparum malaria. Although these treatments are working well in many parts of. Elimination of multidrug resistant malaria the special case of the Greater Mekong Subregion. The Greater Mekong Subregion has long been the epicentre of antimalarial drug resistance. P. falciparum resistance to artemisinin is present in 5 countries of the subregion Cambodia, the Lao People’s Democratic Republic, Myanmar, Thailand and Viet Nam. DRUG RESISTANT MALARIA Chloroquine resistance Chloroquine is ineffective in almost all malaria endemic countries In India chloroquine resistance was first detected in 1973 in Assam. Severe in northeast and southeastern regions of India with high morbidity and mortality.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    Chloroquine resistant falciparum malaria drugs

    On the Mechanism of Chloroquine Resistance in Plasmodium., WHO Responding to antimalarial drug resistance

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  5. This study was carried out to investigate the malaria prevalence and chloroquine-resistant Plasmodium falciparum among malaria patients in hundred and seventy-eight 678 patients demographic and socio-economic information was obtained using a structured questionnaire. 5% Giemsa stained thick blood films from the patients were examined using light microscopy and the samples were also.

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    Sep 15, 2001 Searches for new drugs against chloroquine-resistant malaria, especially as they relate to analogues of chloroquine and chemosensitizing agents against the different forms of P. falciparum and P. vivax, should benefit greatly from research work in this area Jan 10, 2020 Malaria understanding drug resistance. A recent study of the P. falciparum chloroquine-resistance transporter points to mechanisms underlying resistance to chloroquine and piperaquine. Hilary Hurd Chloroquine-resistant P. falciparum also are resistant to hydroxychloroquine 109 and may be cross-resistant to pyrimethamine or quinine. a Cross-resistance between chloroquine and mefloquine reported in P. falciparum and P. vivax in vitro. 152 153

     
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