It is a disabling and painful condition which can lead to substantial loss of mobility due to pain and joint destruction. I really liked the Arava, but I I am now on MTX and Simponi now. The disease is also systemic in that it often also affects many extra-articular tissues throughout the body including the skin, blood vessels, heart, lungs, and... I was on the Orencia when I was on the above two you mentioned. Mp biomedicals chloroquine Hydroxychloroquine pregnancy Plaquenil genetric contraindicated Nov 16, 2017 Just wondering if anyone out there has been put on plaquenil and enbrel together. I noticed on webmed that the 2 should not be taken together as there is a serious potential interaction. I noticed on webmed that the 2 should not be taken together as there is a serious potential interaction. Hi Polly, I'm on all 3. I am doing well enough to walk & participate in an exercise class 3 times a week. I get the occasional pain or flare, but I've gotten to a good place by taking all 3 meds. I take plaquenil daily, Arava/leflunomide on Tues & Fri's, and Methotrexate 8 on Sundays. And I go to an opthamologist twice a year, per my Dr's. CHICAGO – Combination therapy with leflunomide and hydroxychloroquine met all goals for efficacy, safety, and tolerability among patients with primary Sjögren’s syndrome in a randomized, placebo-controlled pilot study, lending support to evidence suggesting the two drugs have additive benefits. The doctor then kept me on my plaquenil and added Leflunomide (Arava) to replace the methotrexate. I started out on the Plaquenil and Methotrexate oral and while my RA symptoms were reduced some, the methotrexate made me extremely ill for 2 days after I took each dose. Arava and plaquenil together Leflunomide-hydroxychloroquine combo shows promise in primary., Hydroxy/ Plaquenil or Leflunomide/ Arava in. - HealthUnlocked Plaquenil package insertHow much is to much plaquenilPlaquenil pros and consPlaquenil for mrsa Over time, leflunomide can reduce the inflammation that makes your joints painful, swollen and stiff. When you’re first prescribed leflunomide, your rheumatologist roo-ma-tolo-jist will monitor your progress. Once they feel your condition has improved, your rheumatologist will probably ask your GP to manage your treatment and prescriptions. Leflunomide Side-effects, uses, time to work. Leflunomide-hydroxychloroquine combo shows promise in primary Sjögren’s.. Plaquenil Oral Interactions with Other Medication. So while having RA and MS together is possible, it is not common. Q2. My best friend has been diagnosed with rheumatoid arthritis and suffers with severe pain much of the time. Although patients with rheumatoid arthritis taking disease-modifying antirheumatic drugs DMARDs are monitored for various medication adverse events, DMARDs, and leflunomide in particular, have effects that are not observed clinically, specifically adverse effects on wound healing. I was on Plaquenil and Arava, plus Orencia for a bit last year, till I finally went off the Plaquenil, which wasn't working. My enzymes went up a slight bit in the beginning and then settled down. It did not affect me nearly as badly as mthx. I was on that for 9 years, and my enzymes got so high I had to stop.