Mutations in HLA genes seem to play a crucial role in the pathogenesis of some cases (but not all), likewise silica, aromatic and chlorinated solvents, ketones, trichloroethylene, welding fumes and white spirits exposure seems to contribute to the condition in a small proportion of affected persons. Vitamin D is implicated in the pathophysiology of the disease. Hydroxychloroquine renal dosing Does plaquenil cause weight gain Cirrus oct plaquenil What is the nursing intervention for hydroxychloroquine Hydroxychloroquine Plaquenil Quinacrine Atabrine Chloroquine Aralen Hydroxychloroquine Plaquenil is the most common anti-malarial treatment for scleroderma. It is occasionally used in combination with quinacrine, when ineffective on its own. Anti-malarial drugs, such as Plaquenil hydroxychloroquine, is often used to manage lupus and can also be effective in scleroderma. Plaquenil is thought to interfere with communication between immune cells, which can suppress the damaging effect of an overly active immune response without raising a patient’s risk of susceptibility to infections. Scleroderma is a chronic disease that causes the skin to become thick and hard, a buildup of scar tissue, and damage to internal organs such as the heart and blood vessels, lungs, stomach and kidneys. Typical scleroderma is classically defined as symmetrical skin thickening, with about 70% of cases also presenting with Raynaud's phenomenon, nail-fold capillary changes and antinuclear antibodies. An inverse correlation between plasma levels of vitamin D and scleroderma severity has been noted and vitamin D is known to play a crucial role in regulating (usually suppressing) the actions of the immune system. Scleroderma plaquenil How effective is Plaquenil for Systemic sclerosis., Lupus and Scleroderma - Scleroderma News Chloroquine side effects in pregnancy May 18, 2019 Diagnosis. Because scleroderma can take so many forms and affect so many different areas of the body, it can be difficult to diagnose. After a thorough physical exam, your doctor may suggest blood tests to check for elevated levels of certain antibodies produced by the immune system. Scleroderma - Diagnosis and treatment - Mayo Clinic. Scleroderma -. Why Are Scleroderma Patients so Stubborn? - Scleroderma News. Scleroderma is a group of autoimmune diseases that may result in changes to the skin, blood vessels, muscles, and internal organs. The disease can be either localized to the skin or involve other organs in addition to the skin. Scleroderma is thought to be an autoimmune disease. This means the symptoms are caused by the body attacking its own healthy tissues. Genes play a role in the disease, but the environment also plays a role. Family members of people with scleroderma have a mildly increased risk of developing scleroderma. I take Plaquenil for MCTD and it really helps my joint pain but it doesn't do anything for the more scleroderma - like features like Raynauds and GI issues, and It will not help Scleroderma lung problems.