It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Differential diagnosis for plaquenil retinopathy Can plaquenil help with fatigue Hydroxychloroquine dosing information. Usual Adult Dose for Malaria Treatment of the acute attack 800 mg 620 mg base followed in 6 to 8 hours by 400 mg 310 mg base, then 400 mg 310 mg base once a day for 2 consecutive days; alternatively, a single dose of 800 mg 620 mg base has also been effective The mean AUC of methotrexate was increased 52% and the mean Cmax was reduced 17% when a single dose of methotrexate was given with a dose of hydroxychloroquine 200 mg oral. Close monitoring for evidence of methotrexate toxicity should be done in patients receiving this combination, especially in those with reduced renal function. In rare cases, hydroxychloroquine can cause visual changes or loss of vision. Such vision problems are more likely to occur in individuals taking high doses for many years, individuals 60 years or older, or those with significant kidney disease. At the recommended dose, development of visual problems due to the medication is rare. Today, it is used to treat rheumatoid arthritis, some symptoms of lupus, childhood arthritis (or juvenile idiopathic arthritis) and other autoimmune diseases. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. Aximum dose of plaquenil Experts debate hydroxychloroquine dosing guidelines in lupus, Plaquenil hydroxychloroquine sulfate dose, indications. Plaquenil heavy legs The maximum daily dose prescribed is 400 mg. In those who are on hemodialysis 200 mg was prescribed after each dialysis session. In those with renal insufficiency, the dose was 200mg daily. Starting in January of 2013, blood levels of hydroxychloroquine were measured at each visit for cohort patients who had been prescribed hydroxychloroquine. Hydroxychloroquine Blood Levels in SLE Clarifying dosing.. Hydroxychloroquine Plaquenil. Hydroxychloroquine Plaquenil Dosing Calculator - MDCalc. Hydroxychloroquine is usually taken with food or milk to prevent stomach upset. The dosage and length of treatment are based on your medical condition and response to therapy. In children, dosage is also based on weight. Apr 10, 2019 Plaquenil hydroxychloroquine belongs to a group of medicines called quinolines. Plaquenil is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. Single 155 mg and 310 mg intravenous doses, peak blood concentrations ranged from 1161 ng/mL to 2436 ng/mL mean 1918 ng/mL following the 155 mg infusion and 6 months following the 310 mg infusion.