Hydroxychloroquine is available as the brand-name drug Plaquenil. Generic drugs usually cost less than the brand-name version. Hydroxychloroquine may be used as part of a combination therapy. Rash from hydroxychloroquine Dangers of plaquenil Plaquenil mechanism of action in lupus Specifically they examined whether users were subjected to excess HCQ dosing per ophthalmology guidelines defined by exceeding 6.5 mg/kg of IBW and 5.0 mg/kg of ABW. Between 20, the frequency of excess HCQ dosing declined from 40% to 36% using IBW and 38% to 30% using ABW. The AAO published dosing and screening recommendations for chloroquine and hydroxychloroquine in 2016, revising previous recommendations published in 2011. The current maximum daily HCQ dose recommended by the AAO is 5 mg/kg of real weight. The 2011 guidelines suggested a maximum dose of 6.5 mg/kg of ideal weight. Hydroxychloroquine comes as a tablet to take by mouth. For prevention of malaria in adults, two tablets are usually taken once a week on exactly the same day of each week. The first dose is taken 1 to 2 weeks before traveling to an area where malaria is common, and then doses are continued for 8 weeks. Hydroxychloroquine is used to treat lupus erythematosus and rheumatoid arthritis. It isn’t fully understood how this drug works to treat lupus erythematosus or rheumatoid arthritis. That means you may need to take it with other drugs. It treats malaria by killing the parasites that cause the disease. Plaquenil weight based dosing Plaquenil Hydroxychloroquine Uses, Dosage, Side Effects., Despite Plaquenil dosing recommendations, retinal toxicity. Drugs used in chloroquine resistant malariaLong-term progression of hydroxychloroquine retinopathy off the drug marmorPlaquenil como funciona An audit of 100 patients seen at any of nine Canadian rheumatology clinics during early 2016 showed that 30% of patients were not on appropriate weight-based hydroxychloroquine dosages, and 13% of patients on the drug had not received a baseline retinal assessment during their first year. Hydroxychloroquine dosage recommendations often ignored.. Hydroxychloroquine MedlinePlus Drug Information. Weight Based Dose Calculator - reference.. Adults. 200 mg 155 mg base to 400 mg 310 mg base PO per day, administered as a single dose or in 2 divided doses. Antimalarials and/or glucocorticoids are of benefit and may be used for the treatment of SLE without major organ manifestations; however, judicious use of hydroxychloroquine is recommended. It takes into account the patient’s weight and risk factors for Plaquenil retinopathy. With the weekly regimens, in some cases, the daily dose may exceed the 5mg/kg/day limit, but the weekly dose does not exceed 35mg/kg/week, the creators explain. Discussion. A risk factor for Plaquenil hydroxychloroquine retinotoxicity is a daily dose that exceeds 5.0 mg of drug per kg of body weight. The tool on the right simply calculates this threshold based on a patient’s real body weight. It’s important to understand that the daily dose is only one risk factor for plaquenil retinotoxicity.