Chewed nails suggest anxiety, buffed nails hint at good grooming, stained nails identify a smoker, blue nails connote oxygen deprivation, and spoon-shaped nails often mean that a patient needs more vitamin B), and a working familiarity with nail “vocabulary” can help pharmacists identify specific nail changes. Drug-induced nail changes can perplex even expert dermatologists, however. Lupus and pregnancy plaquenil Hydroxychloroquine and sunshine Chloroquine mechanism of action immune system Nail symptoms explained Signs you shouldn't ignore. What do ridges on nails, white spots mean? Your nails can signal everything from lung conditions to anemia. Some changes in your nails are due to medical conditions that need attention. See your doctor if you have any of these symptoms discoloration dark streaks, white streaks, or changes in nail color I've been on Plaquenil 400mg a day for almost 4 years. I haven't noticed any skin discoloration but my hair turned grey at a very young age and I've always kept it natural, but as of late it is turning yellowish and my hair dresser thinks it is from the medication. I checked on Mayo Clinic and one of the side effects is hair bleaching. Drug-induced changes may accumulate in, and discolor, the nail or surrounding skin. Most drug-induced nail changes occur when a drug affects the nail epithelia, but drugs can also affect the nail matrix, the nail bed, or the periungual tissue. Plaquenil nail discoloration Drug-induced nail disease DermNet NZ, Nail Abnormalities Symptoms, Causes, and Prevention Plaquenil brand vs genericEffects of plaquenil rx on osteoarthritis Nail discoloration, in which the nails appear white, yellow, or green, can result from different infections and conditions of the skin. In about 50% of cases, discolored nails are a result of infections with common fungi that can be found in the air, dust, and soil. There are many species of fungi that can affect nails. Nail Discoloration Symptoms, Signs, Causes & Treatment. Plaquenil and skin discoloration - Sjogren's World. Drug-Induced Pigmentation Clinical Presentation History.. Nail beds and corneal and retinal changes may also develop; Cytotoxic drugs Busulfan, cyclophosphamide, bleomycin and adriamycin have all produced hyperpigmentation to some degree; Banded or diffuse pigmentation of nails often occurs; Amiodarone Blue-grey pigmentation in sun-exposed areas face and hands Skin Hyperpigmentation with Hydroxychloroquine Hydroxychloroquine Plaquenil is a common trade name is an anti-inflammatory oral medication that is commonly used to treat many autoimmune diseases. In the hair clinic, we use it for diseases such as lichen planopilaris, frontal fibrosing alopecia, Additionally, cases of diffuse skin depigmentation and cutaneous, nail, or gingival hyperpigmentation have been shown. 3. Sunitinib. It is an oral TKI approved by FDA and EMA for the treatment of, metastatic renal cell carcinoma, pancreatic neuroendocrine tumours, and imatinib-resistant GIST.