Why chloroquine has high volume of distribution

Discussion in 'Chloroquine Online' started by LostBomz, 24-Feb-2020.

  1. Igor Well-Known Member

    Why chloroquine has high volume of distribution

    In rough terms, drugs with a high lipid solubility (non-polar drugs), low rates of ionization, or low plasma protein binding capabilities have higher volumes of distribution than drugs which are more polar, more highly ionized or exhibit high plasma protein binding in the body's environment. Volume of distribution may be increased by kidney failure (due to fluid retention) and liver failure (due to altered body fluid and plasma protein binding). The initial volume of distribution describes blood concentrations prior to attaining the apparent volume of distribution and uses the same formula.

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    Bioavailability is 89% for tablets. Peak plasma concentration is reached 1.5 to 3 hours after ingestion. Distribution by route of exposure Protein binding 5O to 65%. Chloroquine accumulates in high concentrations in kidney, liver, lung and spleen, and is strongly bound in melanin-containing cells eye and skin. Red cell concentration is five to ten times the plasma concentration. The volume of distribution at steady state will also be influenced by protein binding and consequently the terminal half-life. Drugs can compete for the same binding site and thus there is the potential for drug-drug interactions, this would be a particular concern for highly protein bound drugs that have a low therapeutic index such as warfarin. Volume of distribution, elimination half-life and clearance were not different for the three regimens, ranging from 250-302 l kg-1, 374-479 h and 0.44-0.58 l h-1 kg-1 respectively. After the first week of all dosage regimens, peak and trough concentrations of chloroquine were above 16 micrograms l-1, sufficiently suppressive for chloroquine-sensitive P. falciparum strains.

    As body composition changes with age, V But this is generally not what happens. Is not a physiologic value; it is more a reflection of how a drug will distribute throughout the body depending on several physicochemical properties, e.g. The unit for Volume of Distribution is typically reported in liters.

    Why chloroquine has high volume of distribution

    PLAQUENIL HYDROXYCHLOROQUINE SULFATE TABLETS, USP DESCRIPTION, Distribution and plasma protein binding Cambridge MedChem.

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  5. Chloroquine was selected as the agent of choice for further studies, as this drug displayed the highest potency as an uptake inhibitor and was previously shown to have a high volume of.

    • A chloroquine-induced macrophage-preconditioning strategy for improved..
    • The pharmacokinetics of three multiple dose regimens of..

    Conversely, it may be decreased in dehydration. Acetylsalicylic acid has a low volume of distribution and is basically distributed in blood, whereas digoxin has a high volume of distribution and is distributed into intravascular space as well as fat and muscle. Hemodialysis removes only the toxins in the intravascular space. The drug has an apparent volume of distribution of 116-285 L/kg in healthy adults. Animal studies indicate that concn of chloroquine in liver, spleen, kidney, and lung are at least 200-700 times higher than those in plasma, and concentration of the drug in brain and spinal cord are at least 10-30 times higher than those in plasma. If the drug distributes into all body water the volume of distribution would increase to approximately = 0.57 l/kg If the drug readily diffuses into the body fat the volume of distribution may increase dramatically, an example is chloroquine which has a = 250-302 l/kg

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