Mutations in HLA genes seem to play a crucial role in the pathogenesis of some cases (but not all), likewise silica, aromatic and chlorinated solvents, ketones, trichloroethylene, welding fumes and white spirits exposure seems to contribute to the condition in a small proportion of affected persons. Vitamin D is implicated in the pathophysiology of the disease. Method of action of chloroquine Is it ok to drink alcohol while taking plaquenil Plaquenil acne Plaquenil swollen face Plaquenil is the brand name for the prescription drug hydroxychloroquine. It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as. Lupus and scleroderma can “cross-over” or have overlapping symptoms and signs. For example, Raynaud’s or esophageal dysfunction is found in 90% with scleroderma but 30% with lupus, swollen joints in half with lupus and 30% with scleroderma, and positive ANA in 98% with lupus and 80% with scleroderma. Anti-malarial drugs, such as Plaquenil hydroxychloroquine, is often used to manage lupus and can also be effective in scleroderma. Plaquenil is thought to interfere with communication between immune cells, which can suppress the damaging effect of an overly active immune response without raising a patient’s risk of susceptibility to infections. Typical scleroderma is classically defined as symmetrical skin thickening, with about 70% of cases also presenting with Raynaud's phenomenon, nail-fold capillary changes and antinuclear antibodies. An inverse correlation between plasma levels of vitamin D and scleroderma severity has been noted and vitamin D is known to play a crucial role in regulating (usually suppressing) the actions of the immune system. Plaquenil forlimited sclera derma Morphea Localized Scleroderma - Dermatology Advisor, Lupus and Scleroderma Overview - Lupus International Plaquenil hair linePlaquenil liver damage testsSide effects plaquenil forums Systemic sclerosis scleroderma is found among people who take Plaquenil, especially for people who are female, 50-59 old, have been taking the drug for 10+ years, also take medication Lasix, and have Osteoporosis Plaquenil and Systemic sclerosis scleroderma - from FDA.. Lupus and Scleroderma - Scleroderma News. How effective is Plaquenil for Systemic sclerosis.. Sources of Pain in Scleroderma. Pain, along with fatigue, is one of the main symptoms of scleroderma and one of the toughest to deal with on a day–to–day basis. Scleroderma News, 05/11/2017. Sleep disturbances in systemic sclerosis SSc evidence for the role of gastrointestinal symptoms, pain and pruritus. This section of the Scleroderma FAQ is focused on standard treatment approaches that are designed either to target the overall disease process or to modify the disease in a way that can potentially improve more than one symptom, for example, bosentan Tracleer for skin ulcers and PAH. Scleroderma is a multisystem disease with variable expression; thus any treatment plan must be holistic yet at the same time focus on the dominant organ disease. The goal of therapy is both to improve quality of life by minimizing specific organ involvement and subsequent life-threatening disease.