I started on it just less than 2 weeks ago, and I'm surrounded by ill people at work and already have a bit of a cold (nothing severe). it is "milder" than a lot of the other dmards in terms of side effects and activity x It is listed as having a mild immunosuppressant effect in my book on RA, but one of the reasons for the blood tests is to check that your immune system is not being suppressed too much (eg checking your white blood cell levels), so you shouldn't be completely vulnerable. Even after several years of taking lots of drugs I've not found any difference in the number of colds etc I get, and loads of people on here are teachers etc who get a lot of exposure to colds and coughs without too much problem. Taking two plaquenil instead of 1.5 Hydroxychloroquine for sjogren's syndrome Anti-DNA antibodies exert their pathogenic effects through deposition as immune complexes in the kidney or through the recognition of cross-reactive antigens in the kidney, while in situ deposition of an immune complex composed of DNA, anti-DNA antibody and IgG in the renal tissue leads to the activation of the complement system and causes a series of immune injury. Tubulointerstitial injury is found frequently in lupus nephritis. PLAQUENIL should be used with caution in patients with hepatic disease or alcoholism, in whom a reduction in dosage may be necessary, or in conjunction with known hepatotoxic drugs. Isolated cases of abnormal liver function tests have been reported; fulminant hepatic failure has also been reported. In SLE, autoantibody production is directed at molecules on the cell surface or in the cytoplasm and nucleus, coagulation factors and immunoglobulin G IgG. 3 The immune dysregulation affects B cells, T cells and cells of monocytic lineage, resulting in polyclonal B cell activation, antibody cell production, autoantibody production, hypergammaglobulinemia and immune complex formation. 3 Also, the phagocytic cells that clear immune complexes are defective in SLE patients. 4 Polly Thank you both, I thought it shouldn't be too bad and that it's pretty mild in comparison to other drugs. Always better to be well informed and I remember the consultant saying its bit a bad time of year to start on it as I've missed all the bugs round Christmas time so thought there may be a slim chance of it being suppressed. But do look after yourself, and make sure you eat well and don't get too tired as if you have a cold already you need to pamper yourself a bit more than you would have before RA. Plaquenil dissolving immune complexes Mechanisms of action of hydroxychloroquine and chloroquine., Plaquenil Hydroxychloroquine Sulfate - Sanofi Chloroquine phosphate tabletsCan you take omeprazole with plaquenilChloroquine in transfectionLexapro and plaquenilWhat lupus symptoms does plaquenil treat Plaquenil hydroxychloroquine belongs to a group of medicines called quinolines. Plaquenil is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. Plaquenil Uses, Dosage & Side Effects -. Lessons on Lupus in the Eye. Hydroxychloroquine directly reduces the binding of.. Clearly, immune activation and the proinflammatory effects mediated by TLRs notably TLRs 2 and 4 on the cell surface, are not inhibited by chloroquine or hydroxychloroquine at the level of ligand binding. Elderberry can increase the immune system. Taking elderberry along with some medications that decrease the immune system might decrease the effectiveness of medications that decrease the immune system.br/br/ Some medications that decrease the immune system include azathioprine Imuran, basiliximab Simulect. Chloroquine and Hydroxychloroquine. Chloroquine and its derivative, hydroxychloroquine sulfate, which have been useful in treating malaria and in larger doses, collagen-vascular disease, cause a cumulative dose-related pigmentary retinopathy.