Although I take Enbrel, and MTX, neither one work as well as the Plaquenil and the fatigue and joint pain have returned full force. I had to get off of plaquenil as well b/c of toxicity and benign tumors behind my eyes. I'm just wondering if any of you here have had to stop taking Plaquenil and if so what you replaced it with? Not knowing what your dx is, I don't know what to tell you. I haven't found a replacement except that I started my cytoxan every month now. Plaquenil increased appetite Ra hydroxychloroquine I can't take plaquenil because it gives me psoriasis. But when I did take it, I got an immediate result which was not expected - more saliva. I had heard from listserves that it could take up to 11 months to work, and that the effect was subtle, subtle enough that many people don't notice it until the STOP taking the drug. The usual starting dose of Plaquenil is 200 mg twice a day or 400 mg once a day, administered orally, in people weighing 80 kg or more. The usual dosage works for most people who take Plaquenil, but it is possible to increase or decrease the dose based on individual needs. It's important to watch for possible side effects and toxicity. I have stopped taking hydroxychloroquine plaquenil as of now, off my own back, because I am sure it makes my reflux worse/causes stomach pain and I can't afford that if I can't take omeprazole. Any suggestions as to what to do instead as I know oodles of you have had both procedures! I also seem to be having a lot of anxiety and I never had this before I stopped my Plaq Am I just losing my mind? All I can do is offer you my sympathy and suggest you talk to your rheumy or hope that others here have an answer for you. I found that some of my symtoms came back after I got off of plaquenil too but I never found something to really "replace it" unforntunately. Yes I do get some kind of strange migraines but without the pain??? (If anything) Since stopping it even the sun is now my worst enemy and I have had to get a pair of sun glasses.. Hi momto3, Wow, I hate to hear that you had to stop taking plaquenil. Since you're taking Enbrel and MTX, I suppose you have RA and I can't imagine having that and not being able to take plaquenil. I have suffered with migraines for thirty years and the only true relief I've ever gotten are from accupuncture and immitrex. I've had other problems as well but I don't think those would help you b/c they are more related to SLE. What else can i take if i cant take plaquenil Hydroxychloroquine Side Effects, Dosage, Uses, and More, Taking Plaquenil for Rheumatoid Arthritis Is plaquenil used to treat vasculitisHydroxychloroquine and platelets what does it meanMethotrexate and plaquenil for lupusHow long plaquenil take to work Apr 02, 2010 there are several drugs now that you can take instead of the plaquenil. these type of drugs they have now work in a different way then the methotrexate and plaquenil. most of these drugs you will still take the methotrexate. i researched these drugs before i made my decision and so for myself i started on the enbril and boy what a difference. Is there a drug that I can take to replace plaquenil?. Gastroscopy, have to stop medication 10 days before? - UK.. Refusing to take Plaquenil - HealthBoards. Plaquenil doesn't usually cause insomnia. It is most likely something else, such as prednisone if you're taking it or anxiety. Insomnia is a common complaint for people with Lupus, some as a result of the steroids and some from general stress of the disease. Lupus is a difficult diagnosis to handle and can really make it difficult to fall asleep. WebMD provides information about which foods to avoid while taking Plaquenil Oral. Skip to main content. WebMD Investigates Why Can't We Sleep. appropriate or effective for you or anyone. Plaquenil is the brand name for the prescription drug hydroxychloroquine. It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as lupus, rheumatoid arthritis, and others.