Malaria parasites can enter the body through these mosquito bites, and then live in body tissues such as red blood cells or the liver. This medication is used to kill the malaria parasites living inside red blood cells. Visual field for plaquenil Hydroxychloroquine blind For treatment of amebiasis, one dose is usually taken for 2 days and then half the dose every day for 2 to 3 weeks. It is usually taken in combination with other amebicides. Chloroquine phosphate may cause an upset stomach. Take chloroquine phosphate with food. Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. Mefloquine is the agent of choice for chloroquine-resistant areas, and evidence suggests it is not associated with an increased risk to the fetus. Although the atovaquone-proguanil drug combination is not currently recommended for use during pregnancy, limited data suggest that it is not harmful to the fetus. Both drugs may be needed for a complete cure and to prevent the return of infection (relapse). In some cases, you may need to take a different medication (such as primaquine) to kill the malaria parasites living in other body tissues. Taking chloroquine in pregnancy Precautions and Warnings With Chloroquine, Hydroxychloroquine Plaquenil Metronidazole and levofloxacin and hydroxychloroquineMalaria prophylaxis chloroquine dose Pregnancy and Chloroquine According to the Centers for Disease Control and Prevention CDC, chloroquine is considered safe to use during pregnancy. Tell your doctor if you're pregnant or might. Chloroquine Aralen - Side Effects, Dosage, Interactions.. Prophylactic use of antimalarials during pregnancy. Malaria Prophylaxis – Malaria Site. Hydroxychloroquine Plaquenil is a drug that is classified as an anti-malarial drug. Plaquenil is prescribed for the treatment or prevention of malaria. It is also prescribed for the treatment of rheumatoid arthritis, lupus, and the side effects of lupus such as hair loss, joint pain, and more. Taking chloroquine during pregnancy is not expected to cause any problems that would require extra monitoring of your baby. However, if you have had malaria during your pregnancy your doctor may wish to monitor your pregnancy more closely. See WARNINGS, Usage in Pregnancy. Nursing Mothers. Because of the potential for serious adverse reactions in nursing infants from chloroquine, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the potential clinical benefit of the drug to the mother.