While many of these can be grouped by anatomic location or type of toxicity, there are also individual medications with characteristic effects. In this article, we will describe several major categories of pharmacologic retinal toxicity and discuss examples of individual medications. Hydroxychloroquine nursing interventions Hydroxychloroquine cause yellow sweat stains Animal model plaquenil Plaquenil ® hydroxychloroquine sulfate is a white or practically white, crystalline powder, freely soluble in water; practically insoluble in alcohol, chloroform, and in ether. The chemical name for hydroxychloroquine sulfate is 2-4-7-Chloro-4-quinolylaminopentylethylamino ethanol sulfate 11. The other day when I was at the opthamologist, for my visual field test for plaquenil, the assistant said I needed to be dilated because "having macular degeneration means thatyou need to be dialted every 6 months" I replied, no. I don't need to be dilated because I don't have macular degeneration. Risk of Toxicity The risk of toxicity is dependent on daily dose and duration of use. At recommended doses, the risk of toxicity up to 5 years is under 1% and up to 10 years is under 2%, but it rises to almost 20% after 20 years. However, even after 20 years, a patient without toxicity has only a 4% risk. Both medications have been shown to bind melanin and to concentrate in the iris, ciliary body and retinal pigment epithelium, altering normal physiologic function. Chloroquine (Aralen) and hydroxychloroquine (Plaquenil) are traditional antimalarial agents now used in the treatment of autoimmune diseases, including rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). Plaquenil macular edema Plaquenil Side Effects Common, Severe, Long Term -, Macular degeneration and lupus" Lupus Community - Support Group On hydroxychloroquineAsians and plaquenil toxicityChemical structure of chloroquine Dec 17, 2019 Macular edema occurs when fluid builds up in the retina—the light sensitive tissue in the back of the eye. This causes swelling and can distort vision. The macula, in the center of the retina, helps us see fine detail and color —it delivers images to us at a higher resolution than any camera or screen. What Is Macular Edema? - American Academy of Ophthalmology. Drug induced maculopathy - EyeWiki. Common Medications That May Be Toxic to the Retina. The aim of this study is to report a rare case of macular edema as a presentation of hydroxychloroquine-related retinal toxicity. We presented a case of a 46-year-old female patient using hydroxychloroquine for underlying rheumatoid arthritis RA with blurred vision over the left eye. Plaquenil is known to show retinal toxicity which can effect the vision and it is imperative. • Cystoid macular edema sometimes may develop, 11 and advanced cases show widespread RPE and retinal atrophy with loss of visual acuity, peripheral vision, and night vision. H ydroxychloroquine HCQ; Plaquenil, Sanofi, Bridgewater, NJ is an antimalarial agent that is also commonly used as a treatment for a variety of rheumatologic and dermatologic conditions, such as rheumatoid arthritis and systemic lupus erythematosus.