Although survival rates have improved, over one half of patients with systemic lupus erythematosus have permanent damage in one or more organ systems. Arthritis and cutaneous manifestations are most common, but renal, hematologic and neurologic manifestations contribute largely to morbidity and mortality. Plaquenil and motrin Side effects of malaria pills chloroquine Chloroquine treatment typing discrepancy In addition, lenalidomide may be useful in some patients. 30 Hydroxychloroquine is the first-line systemic agent for discoid lupus erythematosus DLE, whereas chloroquine is considered. Hydroxychloroquine is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Important information. Taking hydroxychloroquine long-term or at high doses may cause irreversible damage to the retina of your eye. THIS study was undertaken as a clinical evaluation of the treatment of lupus erythematosus with a tablet composed of quinacrine, 25 mg. hydroxychloroquine, 50 mg. and chloroquine, 65 mg.¶ Certain antimalarial drugs have been shown to be more effective than any therapy previously available in treatment of chronic discoid lupus erythematosus. Systemic lupus erythematosus has fascinated physicians for almost a century and remains the prototypic autoimmune disease. Treatment approaches emphasize using a combination of drugs to minimize chronic exposure to corticosteroids. Treatment of discoid lupus erythematosus with chloroquine Treating Lupus with Anti-Malarial Drugs Johns Hopkins Lupus., Hydroxychloroquine Uses, Dosage & Side Effects - How long do i have to take plaquenilCan someone with glucoma take plaquenilQuinacrine and hydroxychloroquine lupus profundusPlaquenil reviews side effectsWhat is the half life of plaquenil Quinacrine can be added to hydroxychloroquine for greater efficacy in hydroxychloroquine-refractory patients, and chloroquine can be used in place of hydroxychloroquine in patients who are unable to tolerate hydroxychloroquine. Second-line therapies include oral retinoids, immunosuppressives, immunomodulators, biologics, and pulsed dye laser. Cutaneous Lupus Erythematosus Current Treatment Options.. Lupus Erythematosus Treated with a Combination of.. Systematic administration of chloroquine in discoid lupus.. User Reviews for Plaquenil to treat Systemic Lupus Erythematosus. The following information is NOT intended to endorse drugs or recommend therapy. While these reviews might be helpful, they are not a substitute for the expertise, skill, knowledge and judgement of healthcare practitioners in patient care. Treatment of discoid lupus erythematosus Begin treatment with the elimination of foci of chronic infection in the body, the normalization of endocrine disorders. Eliminate other irritating and provoking factors, such as direct sunlight, radiation therapy, cold, drafts, external skin damage. Bjornberg A, Hellgren L. Topical treatment of chronic discoid lupus erythematosus with betamethason-17-valerate and fluocinolone acetonie-a double blind study. Indian J Dermatol 1966;. Mitchell AD, Mitchell DM. Fluocinolone acetonide in the treatment of chronic discoid lupus erythematosus.