Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight. Hydroxychloroquine mechanism of action Metoprolol and plaquenil interaction Arthritis medicine hydroxychloroquine For individuals with significant risk factors daily dose of hydroxychloroquine sulfate 5.0 mg/kg base of actual body weight, subnormal glomerular filtration, use of tamoxifen citrate or concurrent macular disease monitoring should include annual examinations which include BCVA, VF and SD-OCT; for individuals without significant risk factors. Many rheumatologists used Plaquenil for decades, and it seemed safe and well tolerated,” but then ophthalmologists introduced optical coherence tomography OCT to assess retinal damage. OCT “changed our appreciation of the frequency of HCQ damage,” Dr. Rosenbaum said in an interview. Abstract. Background The American Academy of Ophthalmology recommendations on screening for chloroquine CQ and hydroxychloroquine HCQ retinopathy are revised in light of new information about the prevalence of toxicity, risk factors, fundus distribution, and effectiveness of screening tools. Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight. Plaquenil charting and oct The Ultimate Guide to Optometry Billing and Coding., Hydroxychloroquine dosage recommendations often ignored MDedge. What natural resources are used to make the chloroquineCan plaquenil help with fatiguePlaquenil toxicity continuing education The traditional protocol for following patients on Plaquenil therapy consisted of baseline photography as well as annual color vision testing, Amsler grid and 10-2 visual fields annually. 2,3 Under the new guidelines, color vision and Amsler grid testing are no longer considered acceptable screening methods so they have been removed from the protocol. 2,3 However, 10-2 visual fields are still important. Pause the Plaquenil?. Recommendations on Screening for Chloroquine and.. Plaquenil Uses, Dosage & Side Effects -. Plaquenil hydroxychloroquine is in a class of drugs called disease-modifying anti-rheumatic drugs, which are used to decrease inflammation, pain and joint damage. While today it is used to treat autoimmune conditions, such as rheumatoid arthritis and lupus, it was originally used as an anti-malaria drug. Sep 15, 2014 AbstractHydroxychloroquine sulfate HCQ, Plaquenil is an analogue of chloroquine CQ, an antimalarial agent, used for the treatment of systemic lupus erythematosus, rheumatoid arthritis and other autoimmune disorders. Its use has been associated with. Apr 20, 2011 Problems with Plaquenil Use Toxic maculopathy associated with chloroquine use was first documented in the literature five decades ago.1 In the United States, Plaquenil––an analog to chloroquine––is used to treat a variety of conditions, including rheumatoid arthritis, lupus and several distinct inflammatory disorders.