Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Hydroxychloroquine eye exam frequency 5 years for plaquenil to leave eye Chloroquine phoaphate powder Mar 03, 2016 So, I've read the half-life is from 30-60 days. That is one of the reasons I didn't want to take it - that's a long time to stick around. I did read hair loss, photosensitivity, itching area all potential side effects of Plaquenil, so hopefully those will subside soon as the med levels drop. Plaquenil is generally well-tolerated, but side effects are possible. Common side effects linked to Plaquenil include nausea and diarrhea. Taking the medication with food eases nausea for most people taking the drug. Less common side effects include skin rashes, hair thinning, and weakness. Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. How long do plaquenil side effects last Hydroxychloroquine Side Effects Common, Severe, Long Term., Taking Plaquenil for Rheumatoid Arthritis Chloroquine for malaria prophylaxis dosingMsds chloroquine phosphateChloroquine cyanidePrimary care prescribe plaquenil I still believe this to be true, but I am convinced now that plaquenil must have multiple modes of action, one being long term effects, and one being something happening in the short term. There is no way what I experienced over the last 4 days was due to placebo affect. By last night, I was so achy, tired, trouble breathing still, etc. Let me tell you what weaning down from Plaquenil is like.. Hydroxychloroquine Plaquenil. Plaqunil rash -. I started taking Plaquenil, and I'm supposed to be taking two 200mg pills a day, but I'm only taking one for a week to ease into it. So far I've woken up every morning very nauseous and with a lot of stomach pain and fatigue early in the day plus diarhea. I heard the side effects go away after a. Re Methotrexate vs Plaquenil side effects long term and short term The MTX dose for autoimmune disease is about 1/1000 the dose they use in cancer patients. MTX also has a long clinical history, which makes it a trustworthy drug, they'll be no "surprise" side effects. Serious Side Effects of Plaquenil If you are taking Plaquenil long-term, such as for an autoimmune condition, your doctor should regularly check you for potential serious side effects.