Her rheumatologist instructed her to undergo a baseline ocular examination prior to initiating Plaquenil (hydroxychloroquine, Sanofi-Aventis) therapy. Toxic maculopathy associated with chloroquine use was first documented in the literature five decades ago.1 In the United States, Plaquenil––an analog to chloroquine––is used to treat a variety of conditions, including rheumatoid arthritis, lupus and several distinct inflammatory disorders. Although the incidence of macular toxicity is infrequent with Plaquenil use (at a dosage of 200mg or 400mg q.d.), its visual impact can be devastating. Bamm trial chloroquine Chloroquine primaquine Plaquenil and tick bites Malaria tablets side effects chloroquine Sep 13, 2019 inability to move the eyes; increased blinking or spasms of the eyelid; joint or muscle pain; large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, and sex organs; loss of hearing; lower back or side pain; noisy breathing; painful or difficult urination; red irritated eyes; red skin lesions, often with a purple center Jan 05, 2020 Hydroxychloroquine Plaquenil and chloroquine cause ocular toxicity to various parts of the eye such as the cornea, ciliary body, and retina. Chloroquine can also induce cataract formation; however, no reports of hydroxychloroquine and cataract have been reported. This article focuses upon hydroxychloroquine retinopathy. Chloroquine CQ and hydroxychloroquine Plaquenil HCQ have been used for many years, initially for the treatment of malaria but now more commonly for the treatment of inflammatory diseases such as rheumatoid arthritis and lupus 1. It is now considered for new disease applications in diabetes, heart disease and adjunct cancer therapies 2. Initially, central visual acuity may be unaffected, but the patient may notice related paracentral scotomas that often interfere with reading. The associated classic retinal toxicity is described as a bull’s eye maculopathy (ring of depigmented retinal pigment epithelium that spares the foveal area). Eye complications from plaquenil Plaquenil Side Effects Common, Severe, Long Term -, Hydroxychloroquine toxicity - EyeWiki Plaquenil coupon websitePlaquenil combination therapyChloroquine prevention malaria Eye damage due to Plaquenil is not common,” he says. “Rarely will anybody who has good vision and minimal symptoms develop loss of central vision or ability to read if annual screening is done and visual are symptoms reported as soon as they occur so the medication can be stopped if toxicity occurs. Protecting your eyesight when taking Plaquenil Lupus.. Hydroxychloroquine Plaquenil Toxicity and Recommendations.. Conditions Plaquenil-related Eye Problems Eugene Eye Care. I also know that I'm a CYP2D6 poor metabolizer and for me I usually only need a tiny dose of or can't take drugs metabolized by that liver enzyme. Is it even possible to have eye complications this soon? Should I think about stopping now? If you had eye complications from Plaquenil when did you notice? Aug 29, 2014 Retinal toxicity of Plaquenil may manifest itself with subtle disturbances of the retinal pigment epithelium which may eventually lead to complete destruction of the macula in the form of bull’s-eye maculopathy. Several risk factors may increase the likelihood of retinal toxicity from Plaquenil such as. Medication overdoses, drug–drug interactions but also chronic administration of medications at the recommended doses may lead to ocular toxicity. The ocular side effects, screening for eye toxicity and treatment guidelines for anti-inflammatory and immunosuppressive drugs commonly used by rheumatologists are reviewed herein.