Distribution of malaria and chloroquine-resistant

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  1. Delico Moderator

    Distribution of malaria and chloroquine-resistant


    -Suppressive therapy should continue for 8 weeks after leaving the endemic area. Approved indication: For the suppressive treatment of malaria due to Plasmodium vivax, P malariae, P ovale, and susceptible strains of P falciparum CDC Recommendations: 300 mg base (500 mg salt) orally once a week Comments: -For prophylaxis only in areas with chloroquine-sensitive malaria -Prophylaxis should start 1 to 2 weeks before travel to malarious areas; should continue weekly (same day each week) while in malarious areas and for 4 weeks after leaving such areas.

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    Chloroquine-resistant P. falciparum first developed independently in three to four areas in Southeast Asia, Oceania, and South America in the late 1950s and early 1960s. Since then, chloroquine resistance has spread to nearly all areas of the world where falciparum malaria is transmitted. Darker shade chloroquine-resistant malaria. Geographic distribution of mefloquine-resistant malaria-Mefloquine resistant malaria around south pacific around cambodia-Travel to areas without Chloroquine-resistant P. falciparum-Once-a-week use of chloroquine Aralen® alone is recommended for prophylaxis. The samples were processed and analysed using genes–P. falciparum chloroquine-resistant transporter pfcrt and P. falciparum multidrug resistance 1 pfmdr1 via sequencing of PCR amplicon from 2015 to 2017. Malaria occurred throughout the year and P. falciparum accounted for 89% of total malaria cases.

    Approved indication: For acute attacks of malaria due to P vivax, P malariae, P ovale, and susceptible strains of P falciparum CDC Recommendations: Chloroquine-sensitive uncomplicated malaria (Plasmodium species or species not identified): 600 mg base (1 g salt) orally at once, followed by 300 mg base (500 mg salt) orally at 6, 24, and 48 hours Total dose: 1.5 g base (2.5 g salt) Comments: -For the treatment of uncomplicated malaria due to chloroquine-sensitive P vivax or P ovale, concomitant treatment with primaquine phosphate is recommended. 60 kg or more: 1 g chloroquine phosphate (600 mg base) orally as an initial dose, followed by 500 mg chloroquine phosphate (300 mg base) orally after 6 to 8 hours, then 500 mg chloroquine phosphate (300 mg base) orally once a day on the next 2 consecutive days Total dose: 2.5 g chloroquine phosphate (1.5 g base) in 3 days Less than 60 kg: First dose: 16.7 mg chloroquine phosphate/kg (10 mg base/kg) orally Second dose (6 hours after first dose): 8.3 mg chloroquine phosphate/kg (5 mg base/kg) orally Third dose (24 hours after first dose): 8.3 mg chloroquine phosphate/kg (5 mg base/kg) orally Fourth dose (36 hours after first dose): 8.3 mg chloroquine phosphate/kg (5 mg base/kg) orally Total dose: 41.7 mg chloroquine phosphate/kg (25 mg base/kg) in 3 days Comments: -Concomitant therapy with an 8-aminoquinoline compound is necessary for radical cure of malaria due to P vivax and P malariae.

    Distribution of malaria and chloroquine-resistant

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  4. The emergence and spread of drug resistant malaria represents a considerable challenge to controlling malaria. Very few new drugs are in pipeline It is essential to ensure rational deployment of the few remaining effective drugs, to maximize their useful therapeutic life

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    These indicated that although population growth will not substantially change the regional distribution of people at malaria risk, around 400 million births will occur within the boundary of current distribution of malaria by 2010 the date by which the Roll Back Malaria initiative is challenged to halve the world’s malaria burden. Distribution of malaria and chloroquine-resistant Plasmodium falciparum, 1993. Centers for Disease Control and Prevention. Approximately 1,000 cases of malaria are reported each year in the United States in returning travelers. Of the 1016 imported cases reported in 1991, the majority were acquired in Africa 466 cases and India 221 cases. Following the global spread of chloroquine-resistant parasites, the Republic of Congo adopted artemisinin-based combination therapy ACT in 2006 as a first-line treatment for uncomplicated malaria. To assess the impacts after implementation of ACT, a molecular surveillance for anti-malarial drug resistance was conducted in Congo 4 and 9 years after the introduction of ACT.

     
  5. a_polli XenForo Moderator

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  7. ilovoli New Member

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  8. LinDosX Well-Known Member

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