Chloroquine excretion

Discussion in 'Canadian Online Pharmacy' started by svelnik, 02-Mar-2020.

  1. chillinglaska Moderator

    Chloroquine excretion


    Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take chloroquine with all of your drugs and health problems.

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    Chloroquine caused a 3.5 to 28-fold increase in uroporphyrin excretion usually accompanied by fever and ALT elevations 48-69 U/L, with centrolobular necrosis on liver biopsy, thereafter, patients were refractory to the side effects and treatment often induced a clinical remission. Uses Chloroquine is used to prevent or treat malaria caused by mosquito bites in countries where malaria is common. Malaria parasites can enter the body through these mosquito bites, and then live. Chloroquine is an antimalarial agent that has been reported to have distinct affinity to melanin. After single oral administration of 14C-chloroquine at a dose of 20mg kg-1 under non-fasting.

    For all uses of chloroquine: WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Do not start, stop, or change the dose of any drug without checking with your doctor.

    Chloroquine excretion

    Excretion of chloroquine and desethylchloroquine in human., Chloroquine Oral Uses, Side Effects, Interactions.

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  7. Excretion of chloroquine is quite slow, but is increased by acidification of the urine. Chloroquine is deposited in the tissues in considerable amounts. In animals, from 200 to 700 times the plasma concentration may be found in the liver, spleen, kidney, and lung; leukocytes also concentrate the drug.

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    A 16.67 mg chloroquine PHOSPHATE/mL oral suspension equivalent to 10 mg chloroquine BASE/mL may be made from tablets. Crush two 500 mg chloroquine PHOSPHATE tablets equivalent to 300 mg BASE/tablet in a mortar and reduce to a fine powder. Add a small amount of sterile water for irrigation. Chloroquine is rapidly and almost completely absorbed from the gastrointestinal tract. Excretion of chloroquine is quite slow, but is increased by acidification of the urine. Slightly more than half of the urinary drug products can be accounted for as unchanged chloroquine. Large i.m. injections or rapid i.v. Chloroquine undergoes appreciable degradation in the body. The main metabolite is desethylchloroquine, which accounts for one fourth of the total material appearing in the urine; bisdesethylchloroquine, a carboxylic acid derivative, and other metabolic products as yet uncharacterized are found in small amounts.

     
  8. belova Well-Known Member

    studies also provide the percentage of patients positive on day 3, which is an indicator of parasite susceptibility to the artemisinin component of an artemisinin-based combination therapy (ACT). Chloroquine-Resistant Malaria The Journal of Infectious. Chloroquine - an overview ScienceDirect Topics Chloroquine Aralen - Side Effects, Dosage, Interactions - Drugs
     
  9. alisska1986 Moderator

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