This medicine is also sometimes given off-label to help the following conditions: Also, let your doctor know if you drink large amounts of alcohol before starting on this medicine. Your doctor will probably want to order frequent tests to check your body's response to chloroquine. Hydroxychloroquine and fasting Plaquenil malaria dosering Plaquenil side effects teeth Chloroquine was administered to the mice in the first group as 20 mg/kg b.w. once a day for four consecutive days. Quinine at a dose of 20 mg/kg b.w. was given to the mice in the second group for the first day and 10 mg/kg b.w. for the second to fourth day. For treatment of acute attacks of malaria in adults, one dose is usually taken right away, followed by half the dose 6 to 8 hours later and then half the dose once a day for the next 2 days. For prevention and treatment of malaria in infants and children, the amount of chloroquine phosphate is based on the child's weight. Chloroquine can abrogate the lethal cellular effects of low dose-rate LDR radiation in vitro by activating the ataxia-telangiectasia mutated ATM protein. Chloroquine administration prior to radiation has a significant effect on early engraftment of bone marrow cells and on the survival of normal but not ATM null mice strongly suggesting that the in vivo effect like the in vitro effect is ATM dependent. Let your healthcare provider know if your symptoms either don't improve or worsen while taking this medicine. Keep all appointments with your doctor and laboratory. Chloroquine lethal dose Chloroquine C18H26ClN3 - PubChem, Chloroquine MedlinePlus Drug Information Hydroxychloroquine prevalence What Is the Chloroquine Dosage for Preventing Malaria? The usual dosage for malaria prevention in adults is 500 mg once a week. The chloroquine dose in children is based on the child's weight. Children either receive about 8.3 mg per kg of body weight about 3.8 mg per pound of body weight or the adult dose, whichever is less. Chloroquine Dosage - Malaria Home Page. Chloroquine improves survival and. - PubMed Central PMC. Medicines for the Prevention of Malaria While Traveling.. Take chloroquine at least 2 hours before or after taking ampicillin. Chloroquine may decrease the amount of ampicillin in your body and the ampicillin may not work as well. Malaria treatment oral To treat malaria in adults, one dose of oral chloroquine is usually given right away. Then, half the dose is taken six to eight hours later. This is typically followed by half the dose once a day for the next two days. Amebiasis treatment oral To treat amebiasis in adults. The mortality rate in overdose studies for adults varies from 10% to 30%9, 11 and in one severe overdose series, a 90% mortality rate was seen. 12 The fatality rate in children is 80% and survivors were often left with neurologic deficits. 13 The minimal lethal dose in a child is 300 mg of chloroquine base or one tablet.