Listing a study does not mean it has been evaluated by the U. One of the mechanisms responsible for survival of these therapy-resistant hypoxic cells is (macro-)autophagy: a phenomenon in which cells provide themselves with energy (ATP) by digesting their own cell-organelles. Tumor hypoxia is a well-known factor negatively influencing outcome in many solid tumors, including small cell lung cancer. Taking plaquenil over 2 years Hydroxychloroquine plaquenil rheumatoid arthritis Chloroquine phosphate toxic to bacteria These findings support clinical study of chloroquine to lower rates of venous thromboembolism in patients with cancer. Trial registration. This study reports correlative data from two clinical trials that registered with clinicaltrials.gov, NCT01128296 May 21, 2010 and NCT01978184 November 7, 2013. Introduction. Antimalarial drugs, chloroquine and hydroxychloroquine, are promising for cancer treatment. Several clinical trials that have been conducted or are in progress have shown favorable effects of chloroquine as a novel antitumor drug. Although the precise mechanism remains to be determined, the anticancer effects of chloroquine may partially be because of its inhibitory action on. The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials. Thus, chloroquine might very well be able to increase overall survival in small cell lung cancer by sensitizing cells resistant to chemotherapy and radiotherapy. Chloroquine is a potent blocker of autophagy and has been demonstrated in a lab setting to dramatically enhance tumor response to radiotherapy, chemotherapy and even anti-hormonal therapy. Chloroquine cancer clinical trials Abstract CT140 PINC trial Preventing invasive. - Cancer Research, Chloroquine in Cancer Therapy A Double-Edged Sword of. Chloroquine philippinesPlaquenil price in indiaPlaquenil screening optometryHydroxychloroquine aoa Unnecessary cellular organelles and proteins. Cancer cells are thought to use autophagy as a source of energy in the unfavorable metastatic environment, and a number of clinical trials are now revealing the promising role of chloroquine, an autophagy inhibitor, as a novel antitumor drug. On the other hand, however, the Chloroquine in Cancer Therapy A Double-Edged Sword. - Cancer Research. Definition of chloroquine - NCI Drug Dictionary - National Cancer Institute. Study protocol of a phase IB/II clinical trial of metformin and.. Chloroquine is a potent blocker of autophagy and has been demonstrated in a lab setting to dramatically enhance tumor response to radiotherapy, chemotherapy and even anti-hormonal therapy. Thus, chloroquine might very well be able to increase overall survival in small cell lung cancer by sensitizing cells resistant to chemotherapy and radiotherapy. A Phase 2 Randomized, Double-blind Trial Evaluating the Effects of Chloroquine in Breast Cancer CUBiC The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Since autophagy has been linked to diverse diseases including cancer, it has recently become a very interesting target in breast cancer treatment. Indeed, current clinical trials are trying to use chloroquine or hydroxychloroquine, alone or in combination with other drugs to inhibit autophagy during breast cancer therapy since chemotherapy and.