Chloroquine physical properties

Discussion in 'Canadian Drug' started by Fedorr, 22-Feb-2020.

  1. Lelik08 Moderator

    Chloroquine physical properties

    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    This chapter highlights the description, physical properties, synthesis, pharmokinetics, and toxicity of chloroquine. Chloroquine is white or slightly yellow crystalline powder, which is odorless and bitter in taste. It is very slightly soluble in water but soluble in dilute acids, chloroform, and ether. The antimalarial compounds quinine, chloroquine and mefloquine affect the electrophysiological properties of Cys-loop receptors and have structural similarities to 5-HT3 receptor antagonists. They may therefore act at 5-HT3 effects. Chloroquine is the drug of choice in the few malaria-endemic areas free of CRPf. Combining chloroquine and proguanil is an option for CRPf when other first-line antimalarials are contraindicated. Dosage should be calculated in terms of the base. The adult chloroquine dose is 300 mg base weekly or in some countries 100 mg base daily.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    Chloroquine physical properties

    Chloroquine C18H26ClN3 ChemSpider, The antimalarial drugs quinine, chloroquine and mefloquine.

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  7. Chloroquine enters the red blood cell by simple diffusion, inhibiting the parasite cell and digestive vacuole. Chloroquine then becomes protonated to CQ2+, as the digestive vacuole is known to be acidic pH 4.7; chloroquine then cannot leave by diffusion.

    • Chloroquine - Wikipedia.
    • Chloroquine - an overview ScienceDirect Topics.
    • Chloroquine phosphate C18H32ClN3O8P2 - PubChem.

    Chloroquine concentrates in the food vacuole up to 1000-fold. Chloroquine, exists in unprotonated form, CQ, monoprotonated form, CQ + and diprotonated form, CQ ++ form 13. Unprotonated form of chloroquine is membrane permeable and it freely diffuses into the red blood cell. It then continues to diffuse into the DV. We collect information on chemical structures, identifiers, chemical and physical properties, biological activities, patents, health, safety, toxicity data, and many others. Where does the data in PubChem come from? PubChem records are contributed by hundreds of data sources. Chloroquine phosphate may cause an upset stomach. Take chloroquine phosphate with food. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Use chloroquine phosphate exactly as directed. Do not use more or less of it or use it more often than prescribed by your.

  8. adrenalinux XenForo Moderator

    Acquiring HCQ is easier than CQ in some areas, so I have done some research to find some literature on HCQ. Chloroquine, Past and Present In the Pipeline Effects of chloroquine on viral infections an old drug against today's. Aralen chloroquine Malaria Drug Side Effects & Dosage
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