Treatment of chloroquine resistant malaria in pregnancy

Discussion in 'Canada Pharmacy' started by Mambuta, 20-Mar-2020.

  1. hostingsale New Member

    Treatment of chloroquine resistant malaria in pregnancy


    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    Vivax malaria. Chloroquine remains an effective treatment for vivax malaria in most of the world, although resistance that emerged in Papua New Guinea and Indonesia is spreading. ACTs apart from artesunate-SP are also highly effective for treatment of vivax malaria, and parenteral artesunate is highly effective in the severe vivax disease 31. The treatment of malaria in pregnant women has become more challenging in recent years, as many types of malaria are developing resistance to the standard arsenal of drugs. In locations where the dominant form of malaria is still chloroquine-sensitive, chloroquine can be used safely throughout pregnancy. Jun 17, 1983 Treatment of chloroquine-resistant malaria during pregnancy. Main EK, Main DM, Krogstad DJ. A pregnant 36-year-old Vietnamese refugee with chloroquine-resistant Plasmodium falciparum infection was treated with pyrimethamine and a sulfonamide.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    Treatment of chloroquine resistant malaria in pregnancy

    Chloroquine - FDA prescribing information, side effects., Drugs to Treat Pregnant Woman with Malaria

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  5. Nov 25, 2019 There are no controlled data in human pregnancies. Congenital anomalies were reported in the offspring of one woman being treated with chloroquine 250 to 500 mg daily during pregnancy for SLE; however, chloroquine has been used in the prophylaxis and treatment of malaria during pregnancy without evidence of fetal harm.

    • Chloroquine Use During Pregnancy.
    • Treatment of chloroquine-resistant malaria during pregnancy..
    • Prophylactic use of antimalarials during pregnancy.

    However, if the P. falciparum is known to be resistant to chloroquine as it is in many parts of the world, chloroquine would not be an appropriate treatment. WHO recommends that women in the first trimester of pregnancy with uncomplicated malaria receive 7 days of quinine with clindamycin. A pregnant 36-year-old Vietnamese refugee with chloroquine-resistant Plasmodium falciparum infection was treated with pyrimethamine and a sulfonamide. This treatment produced rapid clearance of the patient's parasitemia and was associated with a resumption of normal fetal and uterine growth. Because. In the United States, treatment options for uncomplicated chloroquine-resistant P falciparum and P vivax malaria in pregnant women are limited to mefloquine or quinine plus clindamycin. Although the limited availability of quinine and increasing resistance to mefloquine limit these options.

     
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    Chloroquine C18H26ClN3 - PubChem The plasma half-life of chloroquine in healthy individuals is generally reported to be 72-120 hr. In one study, serum concentrations of chloroquine appeared to decline in a biphasic manner and the serum half-life of the terminal phase increased with higher dosage of the drug.

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