Malaria is common in areas such as Africa, South America, and Southern Asia. This medicine is not effective against all strains of malaria. Visual field test for hydroxychloroquine Plaquenil during surgery Plaquenil is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Important information. Taking Plaquenil long-term or at high doses may cause irreversible damage to the retina of your eye. Consumer information about the medication HYDROXYCHLOROQUINE - ORAL Plaquenil, includes side effects, drug interactions, recommended dosages, and storage information. Read more about the prescription drug HYDROXYCHLOROQUINE - ORAL. Any vision changes Plaquenil can cause severe and permanent eye damage Easy bruising or bleeding Frequent or severe infections Signs of heart problems, such as swelling of the ankles, shortness of breath, or an irregular heart rhythm arrhythmia Taking hydroxychloroquine long-term or at high doses may cause irreversible damage to the retina of your eye. Hydroxychloroquine is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Easy bleeding plaquenil Hydroxychloroquine Oral Route Side Effects - Mayo Clinic, HYDROXYCHLOROQUINE - ORAL Plaquenil side effects, medical. Hydroxychloroquine liver toxicity Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. Hydroxychloroquine Plaquenil. When to Report Reactions to Plaquenil. Plaquenil vs. Aralen Prescription Treatment for Malaria.. Easy bruising or; bleeding, confusion, unusual thoughts or behavior, or; seizures convulsions. Dosage for Plaquenil. The adult dose of Plaquenil to suppress malaria is 400 mg on the same day each week. The pediatric weekly suppressive dosage is 5 mg/kg of body weight. Tell your doctor immediately if any of these rare but very serious side effects occur severe stomach/abdominal pain, severe nausea/vomiting, easy bleeding/bruising, signs of infection e.g. fever, persistent sore throat, seizures, shortness of breath, swelling ankles/feet, extreme tiredness, dark urine, yellowing eyes/skin. Low platelet count thrombocytopenia can lead to easy bleeding and bruising. Aplastic anemia can lead to fatigue, shortness of breath and weakness. Hearing Disorders. In 2005, Lareb, the Netherlands Pharmacovigilance Centre, reported that it received three reports of permanent hearing loss and tinnitus after long-term Plaquenil use.