Dark-skinned persons may experience generalized pruritus that is not indicative of drug allergy. Retinal toxicity that may occur with long-term high doses of chloroquine used in the treatment of other diseases is extremely unlikely with chloroquine given as a weekly malaria chemosuppressive agent. Plaquenil maculopathy visual field Hydroxychloroquine for leg cramps Chloroquine binds to heme or FP to form the FP-chloroquine complex; this complex is highly toxic to the cell and disrupts membrane function. Action of the toxic FP-chloroquine and FP results in cell lysis and ultimately parasite cell autodigestion. Hydroxychloroquine HCQ, sold under the brand name Plaquenil among others, is a medication used for the prevention and treatment of certain types of malaria. Specifically it is used for chloroquine-sensitive malaria. Other uses include treatment of rheumatoid arthritis, lupus, and porphyria cutanea tarda. It is taken by mouth. Apr 02, 2019 Mechanism of Action. Chloroquine is an antimalarial agent. While the drug can inhibit certain enzymes, its effect is believed to result, at least in part, from its interaction with DNA. However, the mechanism of plasmodicidal action of chloroquine is not completely certain. Activity in vitro and in vivo Because insufficient drug is excreted in breast milk to protect the infant, nursing infants should be given chloroquine. Chloroquine use is suitable for people of all ages and for pregnant women. Chloroquin mechanism Antimalarial drugs animation Chloroquine - YouTube, Hydroxychloroquine - Wikipedia Distribution of malaria and chloroquine-resistantWhat is chloroquine injectionPlaquenil side effects back pain Oct 01, 2018 Mechanism of Action Chloroquine, a 4-aminoquinoline, is an anti-protozoal agent. The precise mechanism by which Chloroquine exhibits activity is not known. Chloroquine, may exert its effect against Plasmodium species by concentrating in the acid vesicles of the parasite and by inhibiting polymerization of heme. It can also inhibit certain enzymes by its interaction with DNA. Chloroquine - FDA prescribing information, side effects and uses. Aralen Chloroquine Uses, Dosage, Side Effects.. Chloroquine & Hydroxychloroquine supporting chemo.. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus 2019-nCoV in vitro. which is in agreement with its putative anti-viral mechanism as a nucleotide analogue. Chloroquine has been proposed several times for the treatment of acute viral diseases in humans without success. The outcomes of some current clinical trials of chloroquine in China have been announced, without access to the data. Chloroquine is a 9-aminoquinoline that has been known since 1934. Specifically synthesised to be used as an antimalarial agent, chloroquine was subsequently shown to have immunomodulatory properties that have encouraged its application in the treatment of autoimmune diseases such as rheumatoid arthritis.