Retinal damage from plaquenil

Discussion in 'Canada Drugs Online' started by Jasmin, 26-Feb-2020.

  1. bosega Well-Known Member

    Retinal damage from plaquenil


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    I am wondering if methotrexate would be a good substitute, even though it causes hair loss in some people too. My rheum did say folic acid helps mitigate hair loss from metho. But they don't really say why plaquenil causes hair loss in some, so I don't know that there's much you can do to stop it. You either get it or you don't. I just joined this forum but I have been treated for SLE Lupus since 2001. I have been on Plaquenil ever since. My last retina scan shows some thinning of the retina so I am being scheduled with a specialist for further testing and I have been told there is a good possibility I will have to stop taking Plaquenil. Although the incidence of macular toxicity is infrequent with Plaquenil use at a dosage of 200mg or 400mg q.d. its visual impact can be devastating. 2,3. The associated classic retinal toxicity is described as a bull’s eye maculopathy ring of depigmented retinal pigment epithelium that spares the foveal area.

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    Retinal damage from plaquenil

    Has anyone experienced plaquenil toxicity with damage to eyes?, Has anyone had retinal damage from Plaquenil? - Lupus.

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  6. Retinal Damage. According to Drugs.com, Plaquenil given for a long term can cause retinal disorders after a few months or years of daily use--especially if the dose exceeds 400mg per day. The risk of retinal damage increases at doses of 600mg to 700mg.

    • Long-Term Side Effects of Plaquenil for Rheumatoid Arthritis.
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    • Conditions Plaquenil-related Eye Problems Eugene Eye Care.

    Ocular findings of HCQ retinal toxicity as detected by various screening modalities. A female patient was diagnosed with HCQ retinal toxicity at the age of 53 years, having taken HCQ for 12 years at 400 mg/day. She was not obese and had no additional risk factors for toxicity. Ocular Irreversible retinal damage has been observed in some patients who had received hydroxychloroquine sulfate. Significant risk factors for retinal damage include daily doses of hydroxychloroquine sulfate greater than 6.5 mg/kg 5 mg/kg base of actual body weight, durations of use greater than five years, subnormal glomerular filtration. Symptoms and SignsMechanism of ToxicityMedication DosageRisk For ToxicityMonitoring GuidelinesConclusion

     
  7. MMONSTERR Guest

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  8. den-71 Well-Known Member

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    Treatment of Rheumatoid Arthritis with Methotrexate Alone. Original Article from The New England Journal of Medicine — Treatment of Rheumatoid Arthritis with Methotrexate Alone, Sulfasalazine and Hydroxychloroquine, or a Combination of All Three Medications

    Sulfasalazine and Plaquenil drug interactions - eHealthMe