It is bioactivated hepatically to its primary metabolite, N-desethylamodiaquine, by the cytochrome p450 enzyme CYP2C8. Among amodiaquine users, several rare but serious side effects have been reported and linked to variants in the CYP2C8 alleles. Chloroquine phosphate show up on drug test Leukemia and plaquenil What can you mix.with chloroquine for fish Chloroquine is rapidly and almost completely absorbed from the gastrointestinal tract, and only a small proportion of the administered dose is found in the stools. Approximately 55% of the drug in the plasma is bound to nondiffusible plasma constituents. Excretion of chloroquine is quite slow, but is increased by acidification of the urine. An aminoquinoline that is quinoline which is substituted at position 4 by a 5-diethylaminopentan-2-ylamino group at at position 7 by chlorine. Chloroquine CAS NO.54-05-7 has long been used in the treatment or prevention of malaria. After the malaria parasite Plasmodium falciparum started to develop widespread resistance to chloroquine, new potential utilisations of this cheap and widely available drug have been investigated. People who are poor metabolizers of amodiaquine display lower treatment efficacy against malaria, as well as increased toxicity. CYP2C8*1 is characterized as the wild-type allele, which shows an acceptable safety profile, while CYP2C8*2, *3 and *4 all show a range of "poor metabolizer" phenotypes. Iupac name of chloroquine Chloroquine Oral Uses, Side Effects, Interactions, Pictures., Chloroquine C18H26ClN3 ChemSpider Rosuvastatin and hydroxychloroquine Structure, properties, spectra, suppliers and links for Chloroquine Phosphate, 1446-17-9. Chloroquine Phosphate C18H29ClN3O4P ChemSpider. Chloroquine supplier CasNO.54-05-7. Amantadine - Wikipedia. ChEBI Name hydroxychloroquine ChEBI ID CHEBI5801 Definition An aminoquinoline that is chloroquine in which one of the N-ethyl groups is hydroxylated at position 2antimalarial with properties similar to chloroquine that acts against erythrocytic forms of malarial parasites, it is mainly used as the sulfate salt for the treatment of lupus erythematosus, rheumatoid arthritis, and light. Amodiaquine is a 4-aminoquinoline compound related to chloroquine. Amodiaquine was first made in 1948. It is on the World Health Organization's List of Essential Medicines, the safest and most effective medicines needed in a health system. The wholesale cost is about US$0.01 per dose as of 2014. Chloroquine - chemical information, properties, structures, articles, patents and more chemical data.