This medicine is also sometimes given off-label to help the following conditions: Also, let your doctor know if you drink large amounts of alcohol before starting on this medicine. Your doctor will probably want to order frequent tests to check your body's response to chloroquine. Plaquenil pill shape Can u get high on hydroxychloroquine May 26, 2017 Chloramphenicol is known to have hemolytic effects, and there was no further evidence in the literature of an association of monotherapy chloroquine use and hemolytic anemia 12. Based on this information, monotherapy with chloroquine was considered safe to use in patients with a G6PDH deficiency 12. Serious side effects are rare. The most common side effects are nausea and diarrhea, which often improve with time. Less common side effects include rash, changes in skin pigment such as darkening or dark spots, hair changes, and muscle weakness. Rarely, hydroxychloroquine can lead to anemia in some individuals. While pernicious anemia is defined as anemia resulting from inadequate absorption of vitamin B-12 from the gastrointestinal tract due to the autoimmune process described above, other causes of vitamin B-12 deficiency can also produce the characteristic signs and symptoms of pernicious anemia. Other potential causes of vitamin B-12 deficiency. Let your healthcare provider know if your symptoms either don't improve or worsen while taking this medicine. Keep all appointments with your doctor and laboratory. Can chloroquine cause anemia Anemia Causes, Symptoms, Diagnosis, Treatments, Hydroxychloroquine Plaquenil Visual field testing for plaquenil toxicityPlaquenil historyChloroquine retinopathyQuinoric or plaquenilPlaquenil treatment Jul 30, 2019 Along with its needed effects, chloroquine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking chloroquine Incidence not known. Anxiety; attempts at killing oneself Chloroquine Side Effects Common, Severe, Long Term -. Pernicious Anemia Vitamin B-12 Deficiency Symptoms and Signs Causes. Rheumatoid Arthritis and Anemia Are They Connected?. Aug 18, 2015 In heterozygous females normal red blood cells can coexist with red blood cells deficient in G6PD, in variable proportion, and this can cause a milder hemolytic anemia when exposed to primaquine. At the same time, there are 180 different genetic variants of G6PD, resulting in different levels of hemolysis 24. Chloroquine may cause hemolysis in glucose-6 phosphate dehydrogenase G-6-PD deficiency. Blood monitoring may be needed as hemolytic anemia may occur, in particular in association with other drugs that cause hemolysis see ADVERSE REACTIONS. Auditory Effects Summary. Hydroxychloroquine Plaquenil is a drug that is classified as an anti-malarial drug. Plaquenil is prescribed for the treatment or prevention of malaria. It is also prescribed for the treatment of rheumatoid arthritis, lupus, and the side effects of lupus such as hair loss, joint pain, and more.