Hi Dr V, I am at a crossroad of considering to go back on Plaquenil . A year ago I proposed to go off Plaquenil after being on it for 22 years. Plaquenil oral uses Natural alternatives for plaquenil What type of vision problems does plaquenil cause The normal dose of Plaquenil is 1 tablet a day 200mg/day. Some doctors recommend 2 a day 400mg/day but we find that 1 a day suits most people – the dose can always be increased for a flare. One of the attractions of this medication is its long ‘half-life’ – it stays in the system for days & weeks. In a new study, about half of patients with systemic lupus erythematosus SLE did not adhere to Hydroxychloroquine Plaquenil® therapy. A cohort of 1,956 people with lupus over the age of 18 were examined. It is now 6 weeks later, I've titrated up to 600mg. per day, and I am SEVERELY depressed, to the point I can't get out of bed some days. I am sicker mentally than I have been for 16 years, and it didn't start until I started the plaquenil. I'm so anxious, I'm agoraphobic and having anger attacks. I have never been agoraphobic in my life. If I had joint or muscle aches, I took care of it by resting, Aleve and ice. At my recent eye exam the doctor mentioned I had reached the plaquenil toxicity level and that my retina cells could die (which do not regenerate! My proposal was based on the fact that I had not had any major inflamation that completely shut me down or keep me from being active. What is the half life of plaquenil Hydroxychloroquine Plaquenil, Only Half of People with Lupus Adhere to Hydroxychloroquine. What's the difference between prime mcqueen and chloroquineGlaucoma and plaquenilPlaquenil erosive arthritis The absorption half-life was approximately 3 to 4 hours and the terminal half-life ranged from 40 to 50 days. The long half-life can be attributed to extensive tissue uptake rather than through decreased excretion. Peak plasma levels of hydroxychloroquine were seen in about 3 to 4 hours. Plaquenil - FDA prescribing information, side effects and uses. PLAQUENIL Side Effects, Reviews by Patients -. Will you have Drug half-life increased with Plaquenil - eHealthMe. Plaquenil pla´kwĕ-nil trademark for a preparation of hydroxychloroquine, an antiinflammatory and antiprotozoal agent used for treatment of malaria, lupus erythematosus, rheumatoid arthritis, and giardiasis. Plaquenil is very effective for the symptoms of achiness and fatigue. However, there might be a price to pay in terms of retinal toxicity especially after taking it for as long as you have. Given that the alopecia had developed while you were on the plaquenil, it's not clear that going back on it will help that symptom much. Plaquenil is also indicated for the treatment of chronic discoid lupus erythematosus and systemic lupus erythematosus in adults, and for the treatment of acute and chronic rheumatoid arthritis in adults. • Postmarketing cases of life-threatening and fatal cardiomyopathy have been reported with use of Plaquenil and chloroquine.