These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Chloroquine ineffective on exo Aralen artritis Plaquenil is a slow-acting drug, meaning that it can take up to 6 months to experience the full benefits of this medication, but it is possible for symptoms to improve in as few as 1 or 2 months. Plaquenil and other antimalarials are the key to controlling lupus long-term, and some lupus patients may be on Plaquenil for the rest of their lives. Taking hydroxychloroquine long-term or at high doses may cause irreversible damage to the retina of your eye. Stop taking hydroxychloroquine and call your doctor at once if you have trouble focusing, if you see light streaks or flashes in your vision, or if you notice any swelling or color changes in your eyes. Long term studies have shown a high rate of termination of hydroxychloroquine treatment in patients with RA. Although it has been shown that discontinuation of treatment with hydroxychloroquine is associated with exacerbation of SLE, long term maintenance rates of treatment with hydroxychloroquine in patients with SLE have not been investigated. If you notice any other effects, check with your healthcare professional. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Other side effects not listed may also occur in some patients. Plaquenil long term Hydroxychloroquine MedlinePlus Drug Information, Plaquenil, Plaquenil Sulfate, Quineprox hydroxychloroquine. Zentiva hydroxychloroquine costPlaquenil lyme cystsChloroquine phosphate for ich Oct 16, 2014 Hydroxychloroquine is often prescribed as long-term therapy for many dermatologic indications, and it may have broader benefits e.g. preventing or improving thrombophilia associated with lupus erythematosus, neonatal lupus erythematosus, diabetes in rheumatoid arthritis and other connective tissue diseases, and as adjunctive therapy in some cancers. How Safe Is Long-Term Hydroxychloroquine?. Continuation of long term treatment with hydroxychloroquine.. Plaquenil Uses, Dosage & Side Effects -. Feb 19, 2020 Long-term studies in animals have not been conducted to evaluate the carcinogenic potential of PLAQUENIL. The mutagenic potential of hydroxychloroquine was not evaluated. However, chloroquine has been shown to be a catalytic inhibitor of DNA repair enzymes topoisomerase II and to produce weak genotoxic effects through this mode of action. During Plaquenil treatment should be evaluated. • In addition, the Plaquenil label no longer lists the following as contraindications presence of retinal or visual field changes attributable to any 4-aminoquinoline compound, or for long-term therapy in children. • A new. Drug Interactions Methotrexate vs plaquenil side effects long term and short term The only problem is the Plaquenil causes severe headaches that interfer with my daily activities also. But the Dr suggested I try Methotrexate instead.